Hwang Jun Won, Lee Jeong-Bum, Kim Boong-Nyun, Lee Ho-Young, Lee Dong-Soo, Shin Min-Sup, Cho Soo-Churl
Division of Child & Adolescent Psychiatry, Department of Neuropsychiatry, Seoul National University Hospital, Chongnogu, Seoul, Korea.
Eur Arch Psychiatry Clin Neurosci. 2006 Apr;256(3):131-7. doi: 10.1007/s00406-006-0613-2. Epub 2006 Apr 20.
A voxel based investigation of cerebral blood flow was conducted to identify brain functional differences during resting state between children with developmental language disorder (DLD) and normal controls.
Using DSM-IV criteria, we selected 21 children with DLD. All children were examined by technetium-99m-HMPAO Brain SPECT. Using SPM analyses, we compared the SPECT images of children with DLD and those of 17 control subjects on a voxel by voxel basis using ANCOVA covarying for age.
Reduced cerebral blood flow in the right putamen,the right inferior parietal cortex, and the left globus pallidus were found in children with DLD versus the controls. However, no area of increased cerebral blood flow was observed in children with DLD compared to the controls.
Though results should be interpreted cautiously, this study confirms the presence of functional defects in the basal ganglia and the inferior parietal lobe during the resting state of the brains of children with DLD. It also gives further evidence for functional deficits in basal ganglia as an important factor in the etiology of DLD.
进行基于体素的脑血流研究，以确定发育性语言障碍（DLD）儿童与正常对照组在静息状态下的脑功能差异。
根据《精神疾病诊断与统计手册》第四版（DSM-IV）标准，我们选取了21名患有DLD的儿童。所有儿童均接受了锝-99m-六甲基丙二胺肟（99mTc-HMPAO）脑单光子发射计算机断层扫描（SPECT）检查。使用统计参数映射（SPM）分析，我们在考虑年龄协变量的情况下，逐体素地比较了DLD儿童与17名对照受试者的SPECT图像。
与对照组相比，DLD儿童右侧壳核、右侧顶下小叶和左侧苍白球的脑血流减少。然而，与对照组相比，未观察到DLD儿童脑血流增加的区域。
尽管结果应谨慎解释，但本研究证实了DLD儿童大脑静息状态下基底神经节和顶下叶存在功能缺陷。这也进一步证明了基底神经节功能缺陷是DLD病因的一个重要因素。
