Talbot Elizabeth A, Gagnon Elizabeth R, Greenblatt Jesse
New Hampshire Department of Health and Human Services, Concord, New Hampshire, USA.
Clin Infect Dis. 2006 May 15;42(10):1455-62. doi: 10.1086/503572. Epub 2006 Apr 13.
A strategy to combat multidrug-resistant (MDR) Salmonella in ground beef is urgently needed. A national multi-disciplinary meeting reviewed the epidemiology of MDR Salmonella infection and contamination in humans, animals, and retail meat. In spite of a recent overall decrease in human MDR Salmonella isolates, certain types, such as Salmonella enterica serotype Newport multidrug-resistant-AmpC strain and Salmonella enterica serotype Typhimurium definitive type (DT) 104, have persisted, and several recent large outbreaks of human infection have occurred. Key agencies that contribute to a safe ground beef supply were represented at the meeting and contributed to the discussion of possible control strategies from the farm to the table. Several of the control strategies suggested are unpopular to some, including restricting the use of antimicrobial agents in food animals, designation of multidrug-resistant Salmonella as an adulterant in ground beef, and improving the mechanisms for product trace-back investigations. Nevertheless, enhanced farm-based animal infection control, judicious veterinary and human antibiotic use, regulatory controls, and consumer practices will lead to important industry, veterinary, and public health outcomes.
迫切需要一种应对碎牛肉中多重耐药（MDR）沙门氏菌的策略。一次全国性多学科会议回顾了人类、动物和零售肉类中MDR沙门氏菌感染及污染的流行病学情况。尽管近期人类MDR沙门氏菌分离株总体有所减少，但某些类型，如肠炎沙门氏菌新港多重耐药AmpC菌株和肠炎沙门氏菌鼠伤寒血清型定型（DT）104仍持续存在，并且最近发生了几起大规模的人类感染疫情。为安全碎牛肉供应做出贡献的关键机构派代表出席了会议，并参与了从农场到餐桌的可能控制策略的讨论。所建议的一些控制策略对某些人来说不受欢迎，包括限制在食用动物中使用抗菌剂、将多重耐药沙门氏菌指定为碎牛肉中的掺假物以及改进产品追溯调查机制。然而，加强基于农场的动物感染控制、合理使用兽医和人类抗生素、监管控制以及消费者行为将带来重要的行业、兽医和公共卫生成果。
