Yilmaz Betül Sever, Ozbek Hanefi, Citoğlu Gülçin Saltan, Uğraş Serdar, Bayram Irfan, Erdoğan Ender
Ankara University, Faculty of Pharmacy, Department of Pharmacognosy, 06100 Ankara, Turkey.
Phytother Res. 2006 Jun;20(6):500-3. doi: 10.1002/ptr.1891.
The present study investigated the analgesic and hepatoprotective activities of a water extract of Ononis spinosa L. (OS) in mice. Analgesic activity was based on the pain thresholds measured with the tail-flick test before administration at 30, 90 and 150 min. The results were analysed with one-way variance analysis. The extract of Ononis spinosa showed analgesic activity equivalent to aspirin at 30 and 90 min and even higher than aspirin with the 50 mg/kg dose. At a dose of 100 mg/kg OS showed an analgesic effect equivalent to aspirin at all time points.The hepatoprotective influence of OS on carbon tetrachloride (CCl(4))-induced acute liver toxicity was also studied. The extract had no significant effect on the increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and bilirubin in CCl(4) treated animals (p > 0.05). Thus, the results reveal that the extract of OS had no hepatoprotective effect on CCl(4)-induced acute liver toxicity.
本研究调查了棘豆（Ononis spinosa L.，OS）水提取物对小鼠的镇痛和肝保护活性。镇痛活性基于在给药前30、90和150分钟用甩尾试验测量的痛阈。结果采用单因素方差分析进行分析。棘豆提取物在30和90分钟时显示出与阿司匹林相当的镇痛活性，在50 mg/kg剂量时甚至高于阿司匹林。在100 mg/kg剂量下，OS在所有时间点均显示出与阿司匹林相当的镇痛效果。还研究了OS对四氯化碳（CCl₄）诱导的急性肝毒性的肝保护作用。该提取物对CCl₄处理动物中升高的天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）和胆红素水平没有显著影响（p>0.05）。因此，结果表明OS提取物对CCl₄诱导的急性肝毒性没有肝保护作用。
