人乳头瘤病毒类型的差异可能会影响早期宫颈癌的临床结果。
Differences in human papillomavirus type may influence clinical outcome in early stage cervical cancer.
作者信息
Dahlgren Liselotte, Erlandsson Fredrik, Lindquist David, Silfverswärd Claes, Hellström Ann-Cathrin, Dalianis Tina
机构信息
Department of Oncology-Pathology, Karolinska Institutet, CancerCentrumKarolinska, Karolinska University Hospital, Solna, 171 76 Stockholm, Sweden.
出版信息
Anticancer Res. 2006 Mar-Apr;26(2A):829-32.
BACKGROUND
The presence of human papillomavirus (HPV), the HPV type and viral load in early stage cervical carcinoma were investigated in order to elucidate whether any of these factors were important for clinical outcome.
PATIENTS AND METHODS
Twelve patients who were disease-free 5 years after diagnosis were matched and compared with 12 patients who died within 2 years. The presence of HPV, HPV type and viral load in their tumours was examined by PCR.
RESULTS
The distribution and load of HPV was similar in the 2 patient groups. HPV-16 was, however, significantly more common in tumours of the surviving patients than in those of patients who died (88.9% and 18.2%, respectively, p = 0.0152).
CONCLUSION
HPV-16 was significantly more common in early stage carcinomas of patients surviving more than 5 years in comparison to early stage carcinomas of patients with a poor prognosis.
背景
研究早期宫颈癌中人乳头瘤病毒（HPV）的存在情况、HPV类型及病毒载量，以阐明这些因素是否对临床结局有重要影响。
患者与方法
将12例诊断后5年无病生存的患者与12例2年内死亡的患者进行匹配并比较。通过聚合酶链反应（PCR）检测其肿瘤中HPV的存在情况、HPV类型及病毒载量。
结果
两组患者中HPV的分布和载量相似。然而，存活患者肿瘤中HPV-16的出现率显著高于死亡患者（分别为88.9%和18.2%，p = 0.0152）。
结论
与预后不良患者的早期宫颈癌相比，HPV-16在生存超过5年患者的早期宫颈癌中显著更常见。
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