Lu Changyu, Zhu Wei, Han Xiahui, Du Xiuzhen, Zhang Hui, Yao Qin, Liu Ting, Zhang Ce
The Affiliated Hospital of Qingdao University, Qingdao, China.
Qilu Hospital, Shandong University, Jinan, China.
Front Oncol. 2024 Dec 30;14:1492498. doi: 10.3389/fonc.2024.1492498. eCollection 2024.
Invasive Stratified Mucin-producing Carcinoma (ISMC) of the cervix is a newly named cervical adenocarcinoma associated with Human Papilloma virus (HPV). Due to its relative rarity, clinical data, pathological features, and molecular characteristics of ISMC are still under exploration. This study aims to retrospectively analyze the clinical data and pathological features of ISMC patients, summarizing the clinical and pathological morphological characteristics of ISMC. Immunohistochemistry for SLC7A11, SLC3A2, and PD-L1 will be performed on tumor tissues from ISMC patients to preliminarily explore potential therapeutic targets for ISMC.
We retrospectively reviewed the electronic medical records and pathological slides of 22 ISMC patients, and performed immunohistochemical staining for solute carrier family 7 member 11 (SLC7A11), solute carrier family 3 member 2 (SLC3A2), and programmed death-ligand 1 (PD-L1).
The patients were aged between 31 and 70 years old. The most common symptoms were abnormal vaginal bleeding and unusual vaginal discharge. HPV testing indicated that the infection rate of HPV type 18 was the highest. All patients underwent extensive hysterectomy and pelvic lymph node dissection. The progression-free survival (PFS) ranged from 3 to 112 months, with a postoperative recurrence rate of 22.7% (5/22). ISMC exhibited diverse characteristic microstructures. Immunohistochemistry results showed that the positive rates of SLC7A11 and SLC3A2 were both 91.0% (20/22). The staining intensity of SLC7A11 in frequent ISMC recurrence cases was significantly stronger than in non-recurrent ISMC cases. PD-L1 positivity was observed in 86.4% (19/22) of cases, defined as having a Combined Positive Score(CPS)≥1.
ISMC demonstrates a high rate of lymph node metastasis and a high recurrence rate, indicating strong invasiveness. Additionally, ISMC exhibits a wide morphological spectrum. SLC7A11, SLC3A2, and PD-L1 are all highly expressed in ISMC tissues. The high expression of SLC7A11 may indicate a high recurrence rate for ISMC. Immunotherapy with checkpoint inhibitors and iron death-related treatments show potential in the treatment of ISMC, with SLC7A11, SLC3A2, and PD-L1 serving as potential therapeutic targets for ISMC.
宫颈浸润性分层黏液腺癌（ISMC）是一种新命名的与人乳头瘤病毒（HPV）相关的宫颈腺癌。由于其相对罕见，ISMC的临床数据、病理特征和分子特征仍在探索中。本研究旨在回顾性分析ISMC患者的临床资料和病理特征，总结ISMC的临床和病理形态学特征。将对ISMC患者的肿瘤组织进行SLC7A11、SLC3A2和PD-L1的免疫组织化学检测，以初步探索ISMC的潜在治疗靶点。
我们回顾性分析了22例ISMC患者的电子病历和病理切片，并对溶质载体家族7成员11（SLC7A11）、溶质载体家族3成员2（SLC3A2）和程序性死亡配体1（PD-L1）进行了免疫组织化学染色。
患者年龄在31至70岁之间。最常见的症状是阴道异常出血和异常阴道分泌物。HPV检测表明，18型HPV的感染率最高。所有患者均接受了广泛子宫切除术和盆腔淋巴结清扫术。无进展生存期（PFS）为3至112个月，术后复发率为22.7%（5/22）。ISMC表现出多样的特征性微观结构。免疫组织化学结果显示，SLC7A11和SLC3A2的阳性率均为91.0%（20/22）。SLC7A11在ISMC频繁复发病例中的染色强度明显强于非复发ISMC病例。86.4%（19/22）的病例观察到PD-L1阳性，定义为联合阳性评分（CPS）≥1。
ISMC显示出较高的淋巴结转移率和复发率，表明其侵袭性较强。此外，ISMC表现出广泛的形态学谱。SLC7A11、SLC3A2和PD-L1在ISMC组织中均高表达。SLC7A11的高表达可能表明ISMC的复发率较高。检查点抑制剂免疫治疗和铁死亡相关治疗在ISMC治疗中显示出潜力，SLC7A11、SLC3A2和PD-L1可作为ISMC的潜在治疗靶点。
