Saito Taiichi, Hama Seiji, Kajiwara Yoshinori, Sugiyama Kazuhiko, Yamasaki Fumiyuki, Arifin Muhamad-Thohar, Arita Kazunori, Kurisu Kaoru
Department of Neurosurgery, Hiroshima University, School of Medicine, Hiroshima, 734-8551, Japan.
Anticancer Res. 2006 Mar-Apr;26(2B):1351-7.
Cerebellar glioblastomas (GBM) are rare tumors whose clinicopathological characteristics are not well understood.
Clinico-immunohistochemical findings were retrospectively analyzed in 43 supratentorial- and 7 cerebellar GBM. The correlation between survival and immunopositivity for p53, epidermal growth factor receptor (EGFR) and Ki-67 in these tumors was statistically analyzed and compared.
Of the 43 patients with supratentorial GBM, 27 (62.8%) were EGFR immunopositive; their survival was significantly shorter than that of the 16 EGFR-negative patients (p=0.0248). There was no significant correlation between survival and p53 immunopositivity (p=0.7870) and Ki-67 labeling index (p =0.7133). All 5 cerebellar GBM patients treated with radio- and chemotherapy were EGFR-immunonegative; they survived significantly longer than patients with supratentorial GBM (p=0.0296) possibly because their EGFR negativity rendered their tumors more highly radiosensitive.
The better prognosis of patients with cerebellar, EGFR-negative tumors compared to patients with supratentorial tumors is due to the higher radiosensitivity of these tumors.
小脑胶质母细胞瘤（GBM）是罕见肿瘤，其临床病理特征尚未完全明确。
对43例幕上GBM和7例小脑GBM的临床免疫组化结果进行回顾性分析。对这些肿瘤中p53、表皮生长因子受体（EGFR）和Ki-67免疫阳性与生存之间的相关性进行统计学分析和比较。
43例幕上GBM患者中，27例（62.8%）EGFR免疫阳性；其生存期明显短于16例EGFR阴性患者（p=0.0248）。生存与p53免疫阳性（p=0.7870）和Ki-67标记指数（p =0.7133）之间无显著相关性。所有5例接受放疗和化疗的小脑GBM患者均为EGFR免疫阴性；他们的生存期明显长于幕上GBM患者（p=0.0296），可能是因为其EGFR阴性使其肿瘤对放疗更敏感。
与幕上肿瘤患者相比，小脑EGFR阴性肿瘤患者预后较好是由于这些肿瘤具有较高的放射敏感性。
