表皮生长因子受体表达在胶质瘤患者中的预后意义

Prognostic significance of epidermal growth factor receptor expression in glioma patients.

作者信息

Li Junhong, Liang Ruofei, Song Chen, Xiang Yufan, Liu Yanhui

机构信息

Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, People's Republic of China.

出版信息

Onco Targets Ther. 2018 Feb 7;11:731-742. doi: 10.2147/OTT.S155160. eCollection 2018.

PURPOSE

There is a great controversy regarding the prognostic significance of epidermal growth factor receptor (EGFR) in glioma patients. The current meta-analysis was conducted to evaluate the effect of abnormal EGFR expression on overall survival in glioma patients.

MATERIALS AND METHODS

A comprehensive literature search of PubMed, EMBASE, Google Scholar, Web of Science, and Cochrane Library was conducted. The combined hazard ratio (HR) and its 95% confidence intervals (CIs) were used to evaluate the association between EGFR expression and survival in glioma.

RESULTS

A total of 476 articles were screened, and 17 articles containing 1,458 patients were selected. The quality assessment of the included studies was performed by the Newcastle-Ottawa Scale. Overexpression of EGFR was found to be an indicator of poor prognosis in overall survival in glioma patients (HR =1.72, 95% CI 1.32-2.25, =0.000, random effect) and glioblastoma multiforme patients (HR =1.57, 95% CI 1.15-2.14, =0.004, random effect). Subgroup analysis was conducted to explore the source of high heterogeneity.

CONCLUSION

This meta-analysis indicated that high expression of EGFR may serve as a biomarker for poor prognosis in glioma patients.

目的

关于表皮生长因子受体（EGFR）在胶质瘤患者中的预后意义存在很大争议。进行当前的荟萃分析以评估EGFR异常表达对胶质瘤患者总生存期的影响。

材料与方法

对PubMed、EMBASE、谷歌学术、科学网和考克兰图书馆进行了全面的文献检索。采用合并风险比（HR）及其95%置信区间（CI）来评估EGFR表达与胶质瘤生存期之间的关联。

结果

共筛选出476篇文章，选取了17篇包含1458例患者的文章。纳入研究的质量评估采用纽卡斯尔-渥太华量表进行。发现EGFR过表达是胶质瘤患者总生存期预后不良的指标（HR = 1.72，95%CI 1.32 - 2.25，P = 0.000，随机效应）以及多形性胶质母细胞瘤患者预后不良的指标（HR = 1.57，95%CI 1.15 - 2.14，P = 0.004，随机效应）。进行亚组分析以探索高异质性的来源。