Otieno C F, Mwendwa F W, Vaghela V, Ogola E N, Amayo E O
Department of Medicine, College of Health Sciences, University of Nairobi. P.O. Box 19676 - 00202, Nairobi, Kenya.
East Afr Med J. 2005 Dec;82(12 Suppl):S173-9. doi: 10.4314/eamj.v82i12.9378.
Patients with type 2 diabetes are at high of cardiovascular events because they have abnormal lipid status compared to their non-diabetic counterparts.
To determine the quantitative lipid profile of ambulatory patients with type 2 diabetes mellitus.
Prospective, cross-sectional descriptive study.
Out-patient diabetic clinic of the Kenyatta National Hospital.
Ambulatory patients with type 2 diabetes but without obvious cardiovascular, renal or foot complications.
A total of 213 patients with type 2 diabetes were studied, 56.8% were females. The age range of the study population was 34 to 86 years, mean(sd) age of females was 54.45 (9.4) years and that of males was 55.83 (9.3) years. The mean body mass index (BMI) of females was 27.85 (6.2) kg/m2 and 25.98 (5.8) kg/m2 for males. The female subjects were more obese than the males in this study. Over 70% of the study participants had total cholesterol > 4.2 mmol/l, 43.8% and 57.6% of the females and males respectively had LDL-C > 2.6 mmol/l , 25.6% of the females and 30% of the males had HDL-C < 1.00 mmol/l. Only a modest proportion of males (28.3%) and females (32.2%) had triglycerides > 1.7 mmol/l. The LDL-C showed a significant positive correlation with age, duration of diabetes, fasting blood glucose, and total cholesterol but no correlation with glycated haemoglobin, body mass index, gender and the mode of glucose-lowering treatment.
There was significant proportion of quantitative dyslipidaemia in the study population especially with the Total--and LDL- cholesterols. Although treatment goals and lipid thresholds for cardiovascular risk in diabetes are not yet well-defined, even by the large randomized trials, high-risk patients with significant quantitative dyslipidaemia would require deliberate effort to correct the abnormal values to reduce the risk status. These high-risk patients without complications but already had significant dyslipidaemia, which enhances the risk of cardiovascular events, certainly required therapeutic intervention.
2型糖尿病患者发生心血管事件的风险较高，因为与非糖尿病患者相比，他们存在脂质异常。
确定2型糖尿病门诊患者的定量血脂谱。
前瞻性横断面描述性研究。
肯雅塔国家医院门诊糖尿病诊所。
无明显心血管、肾脏或足部并发症的2型糖尿病门诊患者。
共研究了213例2型糖尿病患者，其中56.8%为女性。研究人群的年龄范围为34至86岁，女性的平均（标准差）年龄为54.45（9.4）岁，男性为55.83（9.3）岁。女性的平均体重指数（BMI）为27.85（6.2）kg/m²，男性为25.98（5.8）kg/m²。在本研究中，女性受试者比男性更肥胖。超过70%的研究参与者总胆固醇>4.2 mmol/l，女性和男性分别有43.8%和57.6%的低密度脂蛋白胆固醇（LDL-C）>2.6 mmol/l，25.6%的女性和30%的男性高密度脂蛋白胆固醇（HDL-C）<1.00 mmol/l。只有一小部分男性（28.3%）和女性（32.2%）甘油三酯>1.7 mmol/l。LDL-C与年龄、糖尿病病程、空腹血糖和总胆固醇呈显著正相关，但与糖化血红蛋白、体重指数、性别及降糖治疗方式无关。
研究人群中存在相当比例的定量血脂异常，尤其是总胆固醇和LDL-C。尽管糖尿病心血管风险的治疗目标和血脂阈值尚未明确，即使是大型随机试验也未明确，但有显著定量血脂异常的高危患者需要刻意努力纠正异常值以降低风险状态。这些无并发症但已存在显著血脂异常的高危患者，心血管事件风险增加，肯定需要进行治疗干预。
