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采用血脂谱指标算法评估新诊断 2 型糖尿病患者的血脂异常:加纳多马阿长老会医院的一项横断面研究。

Evaluation of Dyslipidaemia Using an Algorithm of Lipid Profile Measures among Newly Diagnosed Type II Diabetes Mellitus Patients: A Cross-Sectional Study at Dormaa Presbyterian Hospital, Ghana.

机构信息

Department of Molecular Medicine, School of Medicine and Dentistry, College of Health Sciences, Kwame Nkrumah University of Science and Technology, PMB, UPO, Kumasi 00233, Ghana.

School of Medical and Health Science, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA 6027, Australia.

出版信息

Medicina (Kaunas). 2019 Jul 21;55(7):392. doi: 10.3390/medicina55070392.

Abstract

: Dyslipidaemia and its associated complications have been reported to increase mortality among type 2 diabetes mellitus (T2DM) patients. However, there is a dearth of data on the incidence of dyslipidemia among Ghanaian patients with T2DM. This study evaluated dyslipidemia among newly diagnosed T2DM patients at Dormaa Presbyterian Hospital, Ghana. : This cross-sectional study recruited a total of 215 participants at the Presbyterian Hospital, Dormaa-Ghana. A well-structured questionnaire was administered to collect demographic data. Predisposing factors of dyslipidemia such as BMI, hypertension, and family history of diabetes were also obtained. Lipid profile was performed on the serum obtained from each respondent. Dyslipidaemia was defined as total cholesterol (TC) >200 mg/dL, triglyceride (TG) >150 mg/dL, low density lipoprotein cholesterol (LDL-c) >100 mg/dL, and high-density lipoprotein cholesterol (HDL-c) <40 in males and <50 mg/dL in females. Combinations of the individual parameters of dyslipidaemia were further evaluated. : Of the total (215) participants, 86 (40%) were males and 129 (60%) were females, representing a ratio of 1:1.5. High total cholesterol was more prevalent in females (69.0%) than males (53.5%). Generally, dyslipidaemia was predominant among those aged >40 years, with the exception of increased LDL-c (25.1%), which was higher among the 20-40 years age group. The male participants exhibited significantly ( < 0.001) higher percentages of all combined measures of dyslipidaemia-such as high TG and reduced HDL-c (77.9%), high TG and elevated LDL-c (75.6%) and high LDL and low HDL (65.1%). BMI was significantly associated with HDL levels ( = 0.02), whereas family history of diabetes was associated with TC ( = 0.004) and TG levels ( = 0.019). : Combined dyslipidaemia is relatively high among newly diagnosed T2DM patients in Ghana, and in those >40 years. Gender is significantly associated with combined dyslipidaemia in T2DM, and males may be at a higher risk than females. BMI and family history of diabetes are potential risk factors of dyslipidaemia in T2DM.

摘要

: 血脂异常及其相关并发症已被报道会增加 2 型糖尿病(T2DM)患者的死亡率。然而,加纳 T2DM 患者血脂异常的发病率数据却很少。本研究评估了加纳多马阿长老会医院新诊断的 T2DM 患者的血脂异常情况。: 这项横断面研究共招募了 215 名在加纳多马阿长老会医院的参与者。通过一份精心设计的问卷收集人口统计学数据。还收集了血脂异常的诱发因素,如 BMI、高血压和糖尿病家族史。从每位受访者的血清中检测血脂谱。血脂异常定义为总胆固醇(TC)>200mg/dL、甘油三酯(TG)>150mg/dL、低密度脂蛋白胆固醇(LDL-c)>100mg/dL 和高密度脂蛋白胆固醇(HDL-c)男性<40mg/dL,女性<50mg/dL。进一步评估了血脂异常各单项参数的组合。: 在 215 名参与者中,86 名(40%)为男性,129 名(60%)为女性,比例为 1:1.5。女性高总胆固醇的患病率(69.0%)高于男性(53.5%)。一般来说,血脂异常在年龄>40 岁的人群中更为普遍,但 20-40 岁年龄组的 LDL-c 升高(25.1%)除外。男性参与者的所有血脂异常综合指标的比例显著(<0.001)较高,如高甘油三酯和低高密度脂蛋白胆固醇(77.9%)、高甘油三酯和升高的 LDL-c(75.6%)以及高 LDL 和低 HDL(65.1%)。BMI 与 HDL 水平显著相关(=0.02),而糖尿病家族史与 TC(=0.004)和 TG 水平相关(=0.019)。: 在加纳新诊断的 T2DM 患者中,以及年龄>40 岁的患者中,联合血脂异常相对较高。性别与 T2DM 患者的联合血脂异常显著相关,男性的风险可能高于女性。BMI 和糖尿病家族史是 T2DM 血脂异常的潜在危险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b006/6681190/cebc62617a40/medicina-55-00392-g001.jpg

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