Herba Ewa, Pojda-Wilczek Dorota, Pojda Stefan M, Plech Agata R, Makowiecka-Obidzińska Katarzyna, Plech Andrzej, Szkilnik Ryszard, Brus Ryszard
Z Katedry i Oddziału Klinicznego Okulistyki Slaskiej Akademii Medycznej w Katowicach Szpital Specjalistyczny nr 1 w Bytomiu.
Klin Oczna. 2005;107(10-12):599-602.
To find out, if any and how deep alterations in visual tract are due to prenatal intoxication by heavy metals such as: cadmium (Cd), lead (Pb), mercury (Hg) and manganese (Mn). The measure of these alterations were the changes in flash visual evoked potentials after prenatal intoxication.
The experiments were carried out on 55 white newborns Wistar rats, which were divided into 5 groups: control group (14 rats), Cd group (12), Pb (6), Hg (14) and Mn (9). The method of the FVEP study was described by Pojda et al.
The latencies of the peaks N1 and P1 were prolonged in the Mn group till 113-118% (p< 0.05). Slight prolongation of N1 latencies about 1% in Cd and Hg groups and of 4% in Pb group were not statistically significant. The differences of P1 latencies were not statistically significant in these groups, compared to the control group. The amplitude of N1 wave decreased in Cd group about 63% and in Mn group of 32% compared to the control (p<0.05). In Hg intoxicated group the N1 amplitude decreased to 56% (p< 0.01). The amplitude of P1 decreased in all intoxicated groups (Hg of 56%, Cd 55%, Mn 49%) statistically significant, except the Pb one, in which even 21% decrease was not significant.
The heavy metals prolonged the latencies and diminished the amplitudes of flash visual evoked potentials, so may be, they are not only neurotoxic but also "ophthalmotoxic" factors.
探究视觉通路是否因镉（Cd）、铅（Pb）、汞（Hg）和锰（Mn）等重金属的产前中毒而发生改变，若有改变，其程度如何。这些改变通过产前中毒后闪光视觉诱发电位的变化来衡量。
对55只白色新生Wistar大鼠进行实验，将其分为5组：对照组（14只大鼠）、镉组（12只）、铅组（6只）、汞组（14只）和锰组（9只）。FVEP研究方法由Pojda等人描述。
锰组中N1和P1峰的潜伏期延长至113 - 118%（p < 0.05）。镉组和汞组中N1潜伏期略有延长约1%，铅组延长4%，但差异无统计学意义。与对照组相比，这些组中P1潜伏期的差异无统计学意义。与对照组相比，镉组N1波幅降低约63%，锰组降低32%（p < 0.05）。汞中毒组中N1波幅降至56%（p < 0.01）。除铅组外，所有中毒组P1波幅均有统计学意义的降低（汞组降低56%，镉组降低55%，锰组降低49%），铅组即使降低21%也无统计学意义。
重金属延长了闪光视觉诱发电位的潜伏期并降低了其波幅，因此它们可能不仅是神经毒性因素，也是“眼毒性”因素。
