哺乳动物C型病毒结构磷蛋白的比较研究。
Comparative studies on the structural phosphoproteins of mammalian type C viruses.
作者信息
Pal B K, McAllister R M, Gardner M B, Roy-Burman P
出版信息
J Virol. 1975 Jul;16(1):123-31. doi: 10.1128/JVI.16.1.123-131.1975.
The major phosphoprotein common to woolly monkey sarcoma virus, gibbon ape lymphosarcoma virus, and type C viruses of the lower mammalian species (mouse, rat, cat), with the exception of the endogenous cat virus (RD-114), is the polypeptide of about 12,000 molecular weight. The protein-phosphate bond in this polypeptide of several viruses is of the phosphoserine variety excepting gibbon ape virus, which contains both phosphoserine and phosphothreonine. The primary phosphoprotein of RD-114 virus and the endogenous baboon type C virus, on the other hand, is the polypeptide of about 15,000 molecular weight which contains phosphothreonine as its phosphoamino acid. A second major phosphoprotein of molecular weight of 10,000 is detected only in viruses genetically related to rat species including those derived from the RPL cell line, from Sprague-Dawley rat embryo cells, and the Kirsten mouse sarcoma virus which was recovered from a mouse erythroblastosis virus after in vivo propagation through rat. These phosphorylated polypeptides of molecular weight 15,000, 12,000, or 10,000 are present in the virion structure in several different but nonrandom phosphorylated states.
除内源性猫病毒（RD - 114）外，绒毛猴肉瘤病毒、长臂猿淋巴瘤病毒以及低等哺乳动物（小鼠、大鼠、猫）的C型病毒共有的主要磷蛋白是分子量约为12,000的多肽。除长臂猿病毒含有磷酸丝氨酸和磷酸苏氨酸外，几种病毒的这种多肽中的蛋白质 - 磷酸键属于磷酸丝氨酸类型。另一方面，RD - 114病毒和内源性狒狒C型病毒的主要磷蛋白是分子量约为15,000的多肽，其磷酸氨基酸为磷酸苏氨酸。仅在与大鼠物种遗传相关的病毒中检测到第二种分子量为10,000的主要磷蛋白，这些病毒包括源自RPL细胞系、Sprague - Dawley大鼠胚胎细胞的病毒，以及通过大鼠体内传代后从小鼠成红细胞增多症病毒中回收的 Kirsten 小鼠肉瘤病毒。这些分子量为15,000、12,000或10,000的磷酸化多肽以几种不同但非随机的磷酸化状态存在于病毒粒子结构中。
Zotero 插件