Leach M J, Pincombe J, Foster G
School of Health Sciences, University of South Australia, North Terrace Adelaide.
J Wound Care. 2006 Apr;15(4):159-67. doi: 10.12968/jowc.2006.15.4.26898.
To evaluate the clinical efficacy of orally administered horsechestnut seed extract in the treatment of venous leg ulcers.
In a prospective triple-blind randomised placebo-controlled trial, 54 patients with venous leg ulcers from a large South Australian community nursing service were randomly allocated to receive horsechestnut seed extract (n=27) or placebo (n=27) for 12 weeks. Ulcers were assessed at weeks 0, 4, 8 and 12 utilising a wound assessment tool and the Alfred/Medseed Wound Imaging System.
The difference between groups in the number of healed leg ulcers and change in wound surface area, depth, volume, pain and exudate was not statistically significant. However, horsechestnut seed extract did have a significant effect on the percentage of wound slough over time (RM-ANOVA F=2.76, p=0.045) and on the number of dressing changes at week 12 (t=-2.71, p=0.009).
Even though horsechestnut seed extract is likely to attenuate the pathogenesis of venous insufficiency and, in turn, facilitate venous ulcer healing, the current study did not statistically support such a claim. However, taking into account the small sample and insufficient power of the trial, and the significant improvement in wound slough and visit frequency, it appears that it may be useful in the management of venous leg ulcers.
评估口服七叶树籽提取物治疗下肢静脉溃疡的临床疗效。
在一项前瞻性三盲随机安慰剂对照试验中，来自南澳大利亚大型社区护理服务机构的54例下肢静脉溃疡患者被随机分配接受七叶树籽提取物（n = 27）或安慰剂（n = 27）治疗12周。在第0、4、8和12周使用伤口评估工具及阿尔弗雷德/ Medseed伤口成像系统对溃疡进行评估。
两组之间愈合的下肢溃疡数量以及伤口表面积、深度、体积、疼痛和渗出物变化的差异无统计学意义。然而，七叶树籽提取物对伤口腐肉百分比随时间的变化有显著影响（重复测量方差分析F = 2.76，p = 0.045），并且对第12周的换药次数有显著影响（t = -2.71，p = 0.009）。
尽管七叶树籽提取物可能会减轻静脉功能不全的发病机制，进而促进静脉溃疡愈合，但目前的研究在统计学上并不支持这一说法。然而，考虑到试验样本量小和效能不足，以及伤口腐肉和就诊频率的显著改善，七叶树籽提取物似乎可能对下肢静脉溃疡的治疗有用。
