Departament of Pharmacy, Federal University of Sergipe, São Cristóvão, Brazil.
Departament of Medicine, Federal University of Sergipe, São Cristóvão, Brazil.
Int Wound J. 2017 Dec;14(6):1019-1024. doi: 10.1111/iwj.12751. Epub 2017 May 9.
The aim of this study was to systematically review the use of medicinal plants for the treatment of varicose ulcers. The databases used in the search were: Medline/Pubmed, Scopus, Cinhal, Lilacs and Web of Science. The selection process was divided into two phases: the reading of titles and abstracts and the full reading of selected articles. The item description was compared with the checklist of the Consolidated Standards of Reporting Trials. The initial search produced 3505 articles and seven were selected for inclusion in the systematic review. Of the included studies, 7 (100%) evaluated the reduction of the ulcer area, 4 (57·14%) evaluated reepithelisation, 2 (28·57%) evaluated bacterial flora and 1 (14·28%) evaluated the oxygen pressure and percutaneous carbon dioxide. The level of evidence rating indicated that five studies (71·42%) were rated at level 2 and two (28·57%) were rated at level 3. The quality assessment was performed using the Jadad scale, which is prevalent in the literature. The quality score of the Jadad questionnaire ranges from 0 to 5; here, the studies analysed had an average of 2·5. A meta-analysis was performed on two studies that analysed the effects of Mimosa tenuiflora hydrogel in the treatment of venous ulcer and included 42 patients with a mean age of 60·5 years and a mean duration of treatment of 10·5 weeks. Heterogeneity was assessed using I ; we obtained a high value of 84%. We concluded that, despite the efficacy of the incorporation of Ageratina pichinchensis into the gel, the hydrogel that incorporated M. tenuiflora appeared to be a promising candidate for the management of venous ulcers.
本研究旨在系统综述药用植物治疗静脉曲张性溃疡的应用。检索使用的数据库包括：Medline/Pubmed、Scopus、Cinhal、Lilacs 和 Web of Science。选择过程分为两个阶段：阅读标题和摘要，以及对选定文章的全文阅读。项目描述与 CONSORT 报告标准清单进行了比较。初步搜索产生了 3505 篇文章，其中 7 篇被纳入系统评价。在纳入的研究中，7 项研究（100%）评估了溃疡面积的减少，4 项研究（57.14%）评估了再上皮化，2 项研究（28.57%）评估了细菌菌群，1 项研究（14.28%）评估了氧压和经皮二氧化碳。证据等级评定表明，5 项研究（71.42%）被评为 2 级，2 项（28.57%）被评为 3 级。使用 Jadad 量表对文献中普遍使用的质量评估进行了分析。Jadad 问卷的质量评分范围为 0-5；在这里，分析的研究平均得分为 2.5。对两项研究进行了荟萃分析，这两项研究分析了 Mimosa tenuiflora 水凝胶治疗静脉溃疡的效果，纳入了 42 名平均年龄为 60.5 岁，平均治疗时间为 10.5 周的患者。使用 I 评估了异质性；我们得到了 84%的高值。我们得出结论，尽管将 Ageratina pichinchensis 掺入凝胶具有疗效，但掺入 M. tenuiflora 的水凝胶似乎是治疗静脉溃疡的有前途的候选物。
