O'Neil Gregory W, Phillips Andrew J
Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309-0215, USA.
J Am Chem Soc. 2006 Apr 26;128(16):5340-1. doi: 10.1021/ja0609708.
A convergent total synthesis of dictyostatin is described. Key features of the synthesis include the use of titanium-mediated cyclizations of (silyloxy)enynes for the synthesis of stereotriads, a subunit coupling by metathesis, and macrocyclization by intramolecular Horner-Wadsworth-Emmons olefination.
本文描述了一种对盘尼西他汀的汇聚式全合成方法。该合成方法的关键特征包括：利用钛介导的（硅烷氧基）烯炔环化反应来合成立体三联体、通过复分解反应进行亚基偶联以及通过分子内霍纳尔-沃兹沃思-埃蒙斯烯化反应进行大环化。
