Pasco Julie A, Henry Margaret J, Wilkinson Laura K, Nicholson Geoffrey C, Schneider Hans G, Kotowicz Mark A
The University of Melbourne, Department of Clinical and Biomedical Sciences, Barwon Health, Geelong, Victoria, Australia.
J Womens Health (Larchmt). 2006 Apr;15(3):295-300. doi: 10.1089/jwh.2006.15.295.
Whereas several epidemiological studies suggest that low dietary intake of vitamins C and E is linked to increased hip fracture in smokers and antioxidants (dietary and endogenous) are reduced in elderly osteoporotic women, none has demonstrated an effect of supplemental antioxidants on bone turnover.
In an observational study of 533 randomly selected women, we investigated the associations among the use of antioxidant supplements, vitamins C and E, serum levels of biochemical markers of bone turnover (C-telopeptide [CTx] and bone-specific alkaline phosphatase [BSAP]), and whole body bone mineral density (BMD).
Twenty-two women were identified as current users of supplemental vitamin C or E. Duration of antioxidant supplement use was negatively associated with age-adjusted and weight-adjusted serum CTx, such that mean CTx levels (natural log transformed) were 0.022 units lower for each year of exposure. No significant differences were detected for adjusted serum BSAP or whole body BMD.
Our results suggest that antioxidant vitamin E or C supplements may suppress bone resorption in nonsmoking postmenopausal women. Coupling of bone formation and resorption may explain the absence of an effect on bone formation markers, given evidence of enhanced effects of antioxidants on osteoblast differentiation; this warrants further investigation. This work adds to the growing body of evidence that antioxidants may play a role in preventing osteoporosis.
尽管多项流行病学研究表明，吸烟者饮食中维生素C和E摄入量低与髋部骨折风险增加有关，且老年骨质疏松女性体内的抗氧化剂（饮食中的和内源性的）减少，但尚无研究证明补充抗氧化剂对骨转换有影响。
在一项对533名随机选取女性的观察性研究中，我们调查了抗氧化剂补充剂、维生素C和E的使用情况，骨转换生化标志物（C端肽[CTx]和骨特异性碱性磷酸酶[BSAP]）的血清水平，以及全身骨密度（BMD）之间的关联。
22名女性被确定为目前正在使用维生素C或E补充剂。抗氧化剂补充剂的使用时长与年龄和体重校正后的血清CTx呈负相关，即每暴露一年，平均CTx水平（自然对数转换后）降低0.022个单位。校正后的血清BSAP或全身BMD未检测到显著差异。
我们的结果表明，抗氧化剂维生素E或C补充剂可能会抑制非吸烟绝经后女性的骨吸收。鉴于有证据表明抗氧化剂对成骨细胞分化有增强作用，骨形成与骨吸收的耦合可能解释了对骨形成标志物无影响的原因；这值得进一步研究。这项工作进一步证明了抗氧化剂可能在预防骨质疏松症中发挥作用。
