Brownbill R A, Ilich J Z
University of Connecticut, School of Allied Health, Storrs, USA.
J Womens Health (Larchmt). 2006 Apr;15(3):261-70. doi: 10.1089/jwh.2006.15.261.
Previous studies suggest a relationship between cardiovascular disease (CVD) and osteoporosis; however, the mechanism of the relationship and whether serum lipids are positively or negatively associated with bone mineral density (BMD) are unclear.
We investigated the relationship among serum lipids, dietary saturated fat, BMD of various skeletal sites, and markers of bone turnover. This was a cross-sectional analysis in 136 Caucasian, healthy, postmenopausal women, who were not taking lipid-lowering medications or drugs affecting bone metabolism. BMD at multiple skeletal sites was assessed by DXA. Concentration of serum triglycerides, cholesterol, osteocalcin (OC), and undercarboxylated osteocalcin (UOC) and urinary cross-linked N-telopeptides were analyzed by routine methods. Saturated fat, total calcium (food and supplements), total vitamin K, alcohol, and energy intake were estimated using 3-day dietary records. Physical activity was assessed and used as a confounder with other anthropometric measurements.
Serum triglycerides were positively related to femoral shaft BMD and serum cholesterol to total body BMD (p < 0.05). Also, subjects with serum triglycerides above the median had significantly higher BMD in femoral Ward's triangle than those below the median (p = 0.037, by ANCOVA). Subjects with a serum cholesterol level of > or =240 mg/dL (cutoff for increased risk for CVD) had significantly higher BMD at the total body and at all sites of the femur (except neck). There was no relationship between serum lipids and markers of bone turnover. Saturated fat intake was not associated with BMD of any skeletal site.
These findings indicate that higher levels of serum triglycerides and cholesterol are positively associated with BMD of various skeletal sites. The mechanism of this association is not clear, and studies are needed to clarify this relationship.
先前的研究表明心血管疾病（CVD）与骨质疏松症之间存在关联；然而，这种关联的机制以及血脂与骨密度（BMD）是正相关还是负相关尚不清楚。
我们研究了血脂、膳食饱和脂肪、不同骨骼部位的骨密度以及骨转换标志物之间的关系。这是一项对136名未服用降脂药物或影响骨代谢药物的健康绝经后白人女性进行的横断面分析。通过双能X线吸收法（DXA）评估多个骨骼部位的骨密度。采用常规方法分析血清甘油三酯、胆固醇、骨钙素（OC）、未羧化骨钙素（UOC）的浓度以及尿交联N-端肽。使用3天饮食记录估计饱和脂肪、总钙（食物和补充剂）、总维生素K、酒精和能量摄入量。评估身体活动情况，并将其与其他人体测量指标一起用作混杂因素。
血清甘油三酯与股骨干骨密度呈正相关，血清胆固醇与全身骨密度呈正相关（p < 0.05）。此外，血清甘油三酯高于中位数的受试者，其股骨Ward三角区的骨密度显著高于低于中位数的受试者（经协方差分析，p = 0.037）。血清胆固醇水平≥240 mg/dL（心血管疾病风险增加的临界值）的受试者，其全身和股骨所有部位（除颈部外）的骨密度显著更高。血脂与骨转换标志物之间无关联。饱和脂肪摄入量与任何骨骼部位的骨密度均无关联。
这些发现表明，较高水平的血清甘油三酯和胆固醇与不同骨骼部位的骨密度呈正相关。这种关联的机制尚不清楚，需要开展研究以阐明这种关系。
