Fujiwara H, Tanaka N, Suzuki T
Department of Ophthalmology, Kawasaki Hospital, Kawasaki Medical School, Okayama, Japan.
Nippon Ganka Gakkai Zasshi. 1991 Nov;95(11):1071-6.
Numerous factors are related to the development of cataract. In particular the effects of free radicals as triggers for the formation of cataracts have recently attracted attention. The oxygen radicals (O2.-) produced by the hypoxanthine-xanthine oxidase system and the hydroxyl radicals (HO.) produced by Fenton reaction were measured using electron spin resonance (ESR) methods. In the present study, we investigated the effects of compounds used as anti-cataract drugs and evaluated their inhibitory effects on radical formation. Pirenoxine and ascorbic acid both caused potent suppression of the radicals.
许多因素与白内障的发生发展有关。特别是自由基作为白内障形成触发因素的作用最近受到了关注。使用电子自旋共振（ESR）方法测量了次黄嘌呤-黄嘌呤氧化酶系统产生的氧自由基（O2.-）和芬顿反应产生的羟基自由基（HO.）。在本研究中，我们研究了用作抗白内障药物的化合物的作用，并评估了它们对自由基形成的抑制作用。吡诺克辛和抗坏血酸均能有效抑制自由基。
