用潮霉素B治疗小鼠冠状病毒性肝炎
Hygromycin B therapy of a murine coronaviral hepatitis.
作者信息
Macintyre G, Curry B, Wong F, Anderson R
机构信息
Department of Microbiology and Infectious Diseases, University of Calgary, Alberta, Canada.
出版信息
Antimicrob Agents Chemother. 1991 Oct;35(10):2125-7. doi: 10.1128/AAC.35.10.2125.
Abstract
Hepatitis caused by mouse hepatitis virus (MHV-A59), a murine coronavirus, is accompanied by direct infection and replication of virus within the liver. We demonstrate here that the aminoglycoside hygromycin B is able to eliminate MHV-A59 infection from mouse peritoneal macrophages and cultured liver cells in vitro and is also able to reduce levels of virus replication and necrotic liver foci in vivo.
摘要
由鼠冠状病毒小鼠肝炎病毒（MHV - A59）引起的肝炎，伴随着病毒在肝脏内的直接感染和复制。我们在此证明，氨基糖苷类潮霉素B能够在体外消除小鼠腹膜巨噬细胞和培养的肝细胞中的MHV - A59感染，并且在体内也能够降低病毒复制水平和坏死肝灶。
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本文引用的文献
1
MOUSE MACROPHAGES AS HOST CELLS FOR THE MOUSE HEPATITIS VIRUS AND THE GENETIC BASIS OF THEIR SUSCEPTIBILITY.小鼠巨噬细胞作为小鼠肝炎病毒的宿主细胞及其易感性的遗传基础
Proc Natl Acad Sci U S A. 1960 Aug;46(8):1065-75. doi: 10.1073/pnas.46.8.1065.
2
Intracellular accumulation of a fluorescent derivative of paromomycin in human fibroblasts.
J Cell Biochem. 1982;20(1):71-80. doi: 10.1002/jcb.240200108.
3
Molecular biology of animal virus infection.动物病毒感染的分子生物学
Pharmacol Ther. 1980;9(3):311-55. doi: 10.1016/0163-7258(80)90022-4.
4
Neutral-red uptake by amniotic-fluid macrophages in neural-tube defects: a rapid test.
N Engl J Med. 1984 May 31;310(22):1463-4. doi: 10.1056/nejm198405313102217.
5
Augmentation of organ-associated natural killer activity by biological response modifiers. Isolation and characterization of large granular lymphocytes from the liver.生物反应调节剂增强器官相关自然杀伤活性。从肝脏中分离和鉴定大颗粒淋巴细胞。
J Exp Med. 1984 Nov 1;160(5):1431-49. doi: 10.1084/jem.160.5.1431.
6
Control of mouse hepatitis virus replication in macrophages by a recessive gene on chromosome 7.7号染色体上的一个隐性基因对巨噬细胞中鼠肝炎病毒复制的控制
J Immunol. 1984 Jul;133(1):428-32.
7
Inhibition of animal virus production by means of translation inhibitors unable to penetrate normal cells.
Virology. 1980 Oct 15;106(1):123-32. doi: 10.1016/0042-6822(80)90227-5.
8
Uptake and intracellular localization of kanamycin and gentamycin in the lysosomes of cultured fibroblasts.
Arch Int Physiol Biochim. 1974 Dec;82(5):1018-9.
9
Translational regulation in mouse hepatitis virus infection is not mediated by altered intracellular ion concentrations.
J Gen Virol. 1987 Aug;68 ( Pt 8):2143-51. doi: 10.1099/0022-1317-68-8-2143.
10
Induction of demyelination by a temperature-sensitive mutant of the coronavirus MHV-A59 is associated with restriction of viral replication in the brain.冠状病毒MHV - A59的温度敏感突变体诱导脱髓鞘与病毒在脑内复制受限有关。
J Gen Virol. 1987 Mar;68 ( Pt 3):703-14. doi: 10.1099/0022-1317-68-3-703.
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