Epstein J B, Phillips K, Sherlock C H
Division of Oral Medicine and Clinical Dentistry, Vancouver General Hospital, B.C., Canada.
Viral Immunol. 1991 Summer;4(2):133-7. doi: 10.1089/vim.1991.4.133.
Bone marrow transplantation (BMT) may change the recipient's pretransplant serostatus for herpes group viruses. We reviewed 68 patient records (1 year's transplants) to determine how frequently this occurs. Only 7 had data on serostatus before as well as at days 20 to 35 and greater than 100 after BMT. Serostatus was assessed by complement fixation and ELISA. All patients received a variety of blood-product support after BMT. One patient converted from anti-varicella zoster virus (VZV) positive to negative after BMT and developed clinical chickenpox; an additional patient converted from anti-VZV negative to positive after BMT but reverted to seronegative by day 102. One patient converted from anti-cytomegalovirus (CMV) positive pre-BMT to persistently anti-CMV negative post-BMT (donor: anti-CMV negative). Two patients had a greater than 4-fold fall in anti-herpes simplex (HSV) antibody post-BMT, and both shed HSV after BMT. Most seronegative recipients of marrow from seropositive donors developed herpesvirus antibodies. We conclude that the herpesvirus serostatus of BMT recipients should be determined again after BMT to aid in decisions about antiviral prophylaxis and diagnosis of clinical disease.
骨髓移植（BMT）可能会改变受者移植前针对疱疹病毒组病毒的血清学状态。我们回顾了68份患者记录（1年的移植病例），以确定这种情况发生的频率。只有7例患者有移植前以及BMT后第20至35天和超过100天后的血清学状态数据。血清学状态通过补体结合试验和酶联免疫吸附测定进行评估。所有患者在BMT后均接受了多种血液制品支持。1例患者在BMT后从抗水痘带状疱疹病毒（VZV）阳性转为阴性，并出现临床水痘；另有1例患者在BMT后从抗VZV阴性转为阳性，但在第102天时又恢复为血清阴性。1例患者在BMT前抗巨细胞病毒（CMV）阳性，BMT后持续抗CMV阴性（供者：抗CMV阴性）。2例患者在BMT后抗单纯疱疹病毒（HSV）抗体下降超过4倍，且均在BMT后排出HSV。大多数接受血清阳性供者骨髓的血清阴性受者产生了疱疹病毒抗体。我们得出结论，BMT受者的疱疹病毒血清学状态在BMT后应再次确定，以协助做出关于抗病毒预防和临床疾病诊断的决策。
