Olivieri Bianca P, de Souza Andréa P, Cotta-de-Almeida Vinícius, de Castro Solange L, Araújo-Jorge Tania
Lab. Biologia Celular, Dept. Ultra-estrutura e Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, P.O. 926, 21040-900, Rio de Janeiro, RJ, Brazil.
Exp Parasitol. 2006 Nov;114(3):228-34. doi: 10.1016/j.exppara.2006.02.020. Epub 2006 Apr 18.
Disability and mortality as consequence of Chagas disease is enormous in South America. Recently, the success of the trypanocidal treatment with benznidazole, the only available drug, has been associated with the host immune response. In the current study, the impact of benznidazole administration immediately after the experimental infection with Trypanosoma cruzi was evaluated in the main lymphocyte populations in lymphoid organs. Untreated mice displayed enlargement of spleen and lymph node related to the increased frequency of T and B lymphocytes, respectively. An intense thymus involution with the depletion of CD4(+)CD8(+) double-positive thymocytes also occurred. Benznidazole treatment led to a partial reversion of the spleen and lymph node enlargement related to changes in the frequency of lymphocyte subsets due to infection. Prevention of thymus involution was achieved, with the profile of thymocyte subsets similar to that of non-infected mice. The parasitic load at the onset of T. cruzi infection seems critical to trigger immune system activation.
在南美洲，恰加斯病导致的残疾和死亡率极高。最近，唯一可用药物苯硝唑的杀锥虫治疗的成功与宿主免疫反应有关。在当前研究中，评估了在实验性感染克氏锥虫后立即给予苯硝唑对淋巴器官中主要淋巴细胞群体的影响。未治疗的小鼠脾脏和淋巴结肿大，分别与T淋巴细胞和B淋巴细胞频率增加有关。还出现了严重的胸腺退化，伴有CD4(+)CD8(+)双阳性胸腺细胞耗竭。苯硝唑治疗导致脾脏和淋巴结肿大部分逆转，这与感染引起的淋巴细胞亚群频率变化有关。实现了对胸腺退化的预防，胸腺细胞亚群的特征与未感染小鼠相似。克氏锥虫感染开始时的寄生虫负荷似乎对触发免疫系统激活至关重要。
