应激条件下诱导大肠杆菌染色体mazEF会导致生存能力的不可逆丧失。
Induction of Escherichia coli chromosomal mazEF by stressful conditions causes an irreversible loss of viability.
作者信息
Kolodkin-Gal Ilana, Engelberg-Kulka Hanna
机构信息
Department of Molecular Biology, The Hebrew University-Hadassah Medical School, P.O. Box 12272, Jerusalem 91120, Israel.
出版信息
J Bacteriol. 2006 May;188(9):3420-3. doi: 10.1128/JB.188.9.3420-3423.2006.
Abstract
mazEF is a stress-induced toxin-antitoxin module located on the chromosomes of many bacteria. Here we induced Escherichia coli chromosomal mazEF by various stressful conditions. We found an irreversible loss of viability, which is the basic characteristic of cell death. These results further support our previous conclusion that E. coli mazEF mediation of cell death is not a passive process, but an active and genetically "programmed" death response.
摘要
mazEF是一种存在于许多细菌染色体上的应激诱导毒素-抗毒素模块。在这里，我们通过各种应激条件诱导大肠杆菌染色体上的mazEF。我们发现了一种不可逆的生存能力丧失，这是细胞死亡的基本特征。这些结果进一步支持了我们之前的结论，即大肠杆菌mazEF介导的细胞死亡不是一个被动过程，而是一种主动的、由基因“编程”的死亡反应。
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