大肠杆菌mazEF介导的细胞死亡由多种应激条件触发。
Escherichia coli mazEF-mediated cell death is triggered by various stressful conditions.
作者信息
Hazan Ronen, Sat Boaz, Engelberg-Kulka Hanna
机构信息
Department of Molecular Biology, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
出版信息
J Bacteriol. 2004 Jun;186(11):3663-9. doi: 10.1128/JB.186.11.3663-3669.2004.
Abstract
mazEF is an Escherichia coli suicide module specific for a stable toxin and a labile antitoxin. Inhibiting mazEF expression appeared to activate the module to cause cell death. Here we show that several stressful conditions, including high temperatures, DNA damage, and oxidative stress, also induce mazEF-mediated cell death. We also show that this process takes place only during logarithmic growth and requires an intact relA gene.
摘要
mazEF是大肠杆菌中一种特定于稳定毒素和不稳定抗毒素的自杀模块。抑制mazEF的表达似乎会激活该模块从而导致细胞死亡。在此我们表明，包括高温、DNA损伤和氧化应激在内的几种应激条件也会诱导mazEF介导的细胞死亡。我们还表明，这一过程仅在对数生长期发生，并且需要完整的relA基因。
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