老年女性癌症幸存者的功能受限情况。

Functional limitations in elderly female cancer survivors.

作者信息

Sweeney Carol, Schmitz Kathryn H, Lazovich DeAnn, Virnig Beth A, Wallace Robert B, Folsom Aaron R

机构信息

Health Research Center, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.

出版信息

J Natl Cancer Inst. 2006 Apr 19;98(8):521-9. doi: 10.1093/jnci/djj130.

DOI:10.1093/jnci/djj130

PMID:16622121

Abstract

BACKGROUND

The elderly population, including many who are long-term cancer survivors, is increasing. Aspects of quality of life in elderly cancer survivors are not well understood.

METHODS

Subjects were women who enrolled in a population-based cohort study in 1986. At follow-up in 1997, 25,719 women, at a median age of 72 years, reported on functional limitations. We used logistic regression to calculate prevalence odds ratios (ORs) and proportional hazards regression to calculate prevalence ratios (PRs) for associations between cancer survivor status and functional limitations, adjusting for baseline (precancer) characteristics including obesity, smoking, and diabetes.

RESULTS

Women who were cancer survivors for less than 2 years reported the most functional limitations, but long-term (5 or more years) cancer survivors remained more likely than cohort members who had not had cancer to report that they were unable to do heavy household work (42% of 1068 5-year survivors, versus 31% of 23 501 who never had cancer, multivariable OR = 1.47, 95% confidence interval [CI] = 1.27 to 1.69; PR = 1.22, 95% CI = 1.10 to 1.34), unable to walk a half mile (26% versus 19%, OR = 1.31, 95% CI = 1.1 to 1.54; PR = 1.16, 95% CI = 1.02 to 1.32), and unable to walk up and down stairs (9% versus 6%, OR = 1.34, 95% CI = 1.05 to 1.72; PR = 1.25, 95% CI = 1.00 to 1.56). The increased prevalence of functional limitations was apparent for 5-year survivors of breast cancer and also certain other cancers.

CONCLUSIONS

Our findings support the need to target elderly cancer survivors for interventions to maintain or regain physical function.

摘要

背景

包括许多长期癌症幸存者在内的老年人口正在增加。老年癌症幸存者的生活质量方面尚未得到充分了解。

方法

研究对象为1986年参加一项基于人群的队列研究的女性。在1997年的随访中，25719名中位年龄为72岁的女性报告了功能受限情况。我们使用逻辑回归计算患病率比值比（OR），并使用比例风险回归计算癌症幸存者状态与功能受限之间关联的患病率比（PR），同时对包括肥胖、吸烟和糖尿病在内的基线（癌症前）特征进行调整。

结果

癌症存活时间不足2年的女性报告的功能受限情况最多，但长期（5年或更长时间）癌症幸存者比未患癌症的队列成员更有可能报告自己无法从事繁重的家务劳动（1068名5年幸存者中的42%，而23501名从未患癌症者中的31%，多变量OR = 1.47，95%置信区间[CI] = 1.27至1.69；PR = 1.22，95%CI = 1.10至1.34），无法行走半英里（26%对19%，OR = 1.31，95%CI = 1.1至1.54；PR = 1.16，95%CI = 1.02至1.32），以及无法上下楼梯（9%对6%，OR = 1.34，95%CI = 1.05至1.72；PR = 1.25，95%CI = 1.00至1.56）。乳腺癌以及某些其他癌症的5年幸存者功能受限患病率增加明显。