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结核分枝杆菌的hbhA基因在经空气感染的小鼠肺部特异性上调，但在脾脏中未上调。

The hbhA gene of Mycobacterium tuberculosis is specifically upregulated in the lungs but not in the spleens of aerogenically infected mice.

作者信息

Delogu Giovanni, Sanguinetti Maurizio, Posteraro Brunella, Rocca Stefano, Zanetti Stefania, Fadda Giovanni

机构信息

Institute of Microbiology, Catholic University of the Sacred Hearth, Largo Gemelli 8, 00168 Rome, Italy.

出版信息

Infect Immun. 2006 May;74(5):3006-11. doi: 10.1128/IAI.74.5.3006-3011.2006.

DOI:10.1128/IAI.74.5.3006-3011.2006
PMID:16622240
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1459695/
Abstract

We report that hbhA is differentially regulated during Mycobacterium tuberculosis infection. Upregulation was observed in epithelial cell infection but not in macrophage infection and in the lungs but not in the spleens of infected mice, and it was greater during the early steps of infection, when bacilli disseminate from the site of primary infection.

摘要

我们报告称，hbhA在结核分枝杆菌感染过程中受到差异调节。在上皮细胞感染中观察到上调，但在巨噬细胞感染中未观察到，在感染小鼠的肺部观察到上调，但在脾脏中未观察到，并且在感染早期，当杆菌从原发感染部位播散时，上调更为明显。

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The mycobacterial heparin-binding hemagglutinin is a protective antigen in the mouse aerosol challenge model of tuberculosis.分枝杆菌肝素结合血凝素在小鼠气溶胶攻击肺结核模型中是一种保护性抗原。
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Magnetic resonance imaging of pulmonary lesions in guinea pigs infected with Mycobacterium tuberculosis.感染结核分枝杆菌的豚鼠肺部病变的磁共振成像
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