从衣原体表面切割 N-连接寡糖会影响肺部感染小鼠模型中的感染性。
Cleavage of the N-linked oligosaccharide from the surfaces of Chlamydia species affects infectivity in the mouse model of lung infection.
作者信息
Campbell Lee Ann, Lee Amy, Kuo Cho-chou
机构信息
Department of Pathobiology, University of Washington, Box 357238, Seattle, WA 98195, USA.
出版信息
Infect Immun. 2006 May;74(5):3027-9. doi: 10.1128/IAI.74.5.3027-3029.2006.
Abstract
Previous studies determined that the Chlamydia glycan contains a high-mannose oligosaccharide, which is involved in attachment and infectivity of the organism, and that removal of the glycan decreases infectivity in vitro. The present study demonstrates that treatment of the organism with N-glycanase decreases or ablates infectivity in vivo.
摘要
先前的研究确定，衣原体聚糖含有一种高甘露糖寡糖，它参与该生物体的附着和感染性，并且去除聚糖会降低体外感染性。本研究表明，用N-聚糖酶处理该生物体可降低或消除其体内感染性。
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