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组蛋白样类核结构蛋白在霍乱弧菌定殖、运动性及胆汁依赖性毒力基因表达抑制中的作用

Role of the histone-like nucleoid structuring protein in colonization, motility, and bile-dependent repression of virulence gene expression in Vibrio cholerae.

作者信息

Ghosh Amalendu, Paul Kalidas, Chowdhury Rukhsana

机构信息

Biophysics Division, Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Calcutta 700 032, India.

出版信息

Infect Immun. 2006 May;74(5):3060-4. doi: 10.1128/IAI.74.5.3060-3064.2006.

DOI:10.1128/IAI.74.5.3060-3064.2006
PMID:16622251
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1459692/
Abstract

Bile-mediated repression of virulence gene expression is relieved in a Vibrio cholerae hns mutant. The mutant also exhibited reduced motility due to lower flrA expression, higher in vivo production of the virulence factors, and lower colonization efficiency. The colonization defect of the mutant was due to low FlrA production.

摘要

在霍乱弧菌hns突变体中，胆汁介导的毒力基因表达抑制作用得到缓解。由于flrA表达降低，该突变体还表现出运动性降低、毒力因子在体内的产生增加以及定殖效率降低。该突变体的定殖缺陷是由于FlrA产生量低所致。

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本文引用的文献

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Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner.胆汁酸以不依赖ToxT的方式诱导霍乱弧菌中霍乱毒素的表达。
Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):3028-33. doi: 10.1073/pnas.0409559102. Epub 2005 Feb 7.
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Effect of anaerobiosis on expression of virulence factors in Vibrio cholerae.厌氧环境对霍乱弧菌毒力因子表达的影响。
Infect Immun. 2004 Jul;72(7):3961-7. doi: 10.1128/IAI.72.7.3961-3967.2004.
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Both chemotaxis and net motility greatly influence the infectivity of Vibrio cholerae.趋化性和净运动性都极大地影响霍乱弧菌的传染性。
Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5018-23. doi: 10.1073/pnas.0308052101. Epub 2004 Mar 22.
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The global regulator ArcA modulates expression of virulence factors in Vibrio cholerae.全局调节因子ArcA调节霍乱弧菌中毒力因子的表达。
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An experimental study of the mechanism of action of Vibriod cholerae on the intestinal mucous membrane.霍乱弧菌对肠黏膜作用机制的实验研究
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Regulation of gene expression in Vibrio cholerae by ToxT involves both antirepression and RNA polymerase stimulation.霍乱弧菌中ToxT对基因表达的调控涉及抗阻遏和RNA聚合酶刺激。
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Polar flagellar motility of the Vibrionaceae.弧菌科的极鞭毛运动性。
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Regulation of virulence in Vibrio cholerae.霍乱弧菌毒力的调控
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The novel sigma54- and sigma28-dependent flagellar gene transcription hierarchy of Vibrio cholerae.霍乱弧菌新的依赖于σ54和σ28的鞭毛基因转录层级结构。
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