组蛋白样类核结构蛋白在霍乱弧菌定殖、运动性及胆汁依赖性毒力基因表达抑制中的作用
Role of the histone-like nucleoid structuring protein in colonization, motility, and bile-dependent repression of virulence gene expression in Vibrio cholerae.
作者信息
Ghosh Amalendu, Paul Kalidas, Chowdhury Rukhsana
机构信息
Biophysics Division, Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Calcutta 700 032, India.
出版信息
Infect Immun. 2006 May;74(5):3060-4. doi: 10.1128/IAI.74.5.3060-3064.2006.
Abstract
Bile-mediated repression of virulence gene expression is relieved in a Vibrio cholerae hns mutant. The mutant also exhibited reduced motility due to lower flrA expression, higher in vivo production of the virulence factors, and lower colonization efficiency. The colonization defect of the mutant was due to low FlrA production.
摘要
在霍乱弧菌hns突变体中，胆汁介导的毒力基因表达抑制作用得到缓解。由于flrA表达降低，该突变体还表现出运动性降低、毒力因子在体内的产生增加以及定殖效率降低。该突变体的定殖缺陷是由于FlrA产生量低所致。
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