Klose K E
Department of Microbiology, University of Texas Health Science Center, 78229-3900, USA.
Int J Med Microbiol. 2001 May;291(2):81-8. doi: 10.1078/1438-4221-00104.
Vibrio cholerae causes the diarrheal disease cholera primarily because it expresses a colonization factor (toxin-coregulated pilus; TCP) and a potent toxin (cholera toxin; CT) within the human intestine. While the true environmental signals that induce CT and TCP expression within the intestine remain unknown, much progress has been made identifying the regulatory factors that modulate their expression. Transcriptional regulation of the genes encoding TCP and CT involves a cascade consisting of a number of regulatory factors located on recently acquired mobile genetic elements as well as others residing within the ancestral Vibrio genome. In vivo studies have revealed interesting differences between the regulation of TCP and CT expression in the laboratory and within the intestine.
霍乱弧菌引发腹泻疾病霍乱主要是因为它在人体肠道内表达一种定植因子（毒素共调节菌毛；TCP）和一种强效毒素（霍乱毒素；CT）。虽然在肠道内诱导CT和TCP表达的真正环境信号仍不清楚，但在确定调节它们表达的调控因子方面已经取得了很大进展。编码TCP和CT的基因的转录调控涉及一个级联反应，该级联反应由位于最近获得的移动遗传元件上的一些调控因子以及存在于霍乱弧菌祖先基因组中的其他调控因子组成。体内研究揭示了实验室环境和肠道内TCP与CT表达调控之间有趣的差异。
