Holtgrave E A
Department of orthodontics, Free University of Berlin, FRG.
J Periodontal Res. 1991 Nov;26(6):511-8. doi: 10.1111/j.1600-0765.1991.tb01803.x.
The role of substrate surface characteristics for periodontal regeneration was studied in rats. Cementogenesis was initiated by dental follicle cells retained after dissecting out a molar tooth germ in 5-day-old rats. The tooth germ was substituted by a bone replacement material, namely HAC granules of porous consistency. Tissue blocks were removed after 24 weeks and processed for light and electron microscopic examination. On all HAC surfaces a new cementum-like tissue developed, similar to that of natural root surfaces. The results strongly indicate that the exposure of collagen fibers is not essential in order to achieve new periodontal attachment.
在大鼠中研究了基质表面特性对牙周再生的作用。通过在5日龄大鼠中解剖出磨牙牙胚后保留的牙囊细胞启动牙骨质生成。用一种骨替代材料，即多孔质地的羟基磷灰石颗粒替代牙胚。24周后取出组织块，进行光镜和电镜检查。在所有羟基磷灰石表面都形成了一种新的类牙骨质组织，类似于天然牙根表面的组织。结果有力地表明，为实现新的牙周附着，胶原纤维的暴露并非必不可少。
