Bentivoglio Anna Rita, Daniele Antonio, Albanese Alberto, Tonali Pietro Attilio, Fasano Alfonso
Istituto di Neurologia, Università Cattolica del Sacro Cuore, Roma, Italy.
Mov Disord. 2006 Aug;21(8):1225-9. doi: 10.1002/mds.20889.
The blink rate (BR) during rest, conversation, and reading was assessed in 50 patients with blepharospasm (BS) and in 150 healthy subjects. BR at rest and during conversation was higher in patients with BS. Moreover, 76% of patients had BR higher at rest than during conversation, whereas in 74% of controls, BR was higher during conversation than at rest. The sensitivity and specificity of two parameters (value of BR at rest and pattern rest-BR higher than conversation-BR) in discriminating patients and controls were computed. The best fit was obtained with a rest-BR above 27 blinks per minute. When the two parameters were combined (rest-BR above 27 blinks per minute together with the pattern rest-BR higher than conversation-BR), we obtained a 92.3% sensitivity and a 82.0% specificity in discriminating between BS patients and controls. These findings indicate that specific features of BR can be associated with BS, suggesting that the analysis of BR might be helpful for the diagnosis of BS in early stages.
对50例睑痉挛（BS）患者和150名健康受试者在休息、交谈及阅读时的眨眼频率（BR）进行了评估。BS患者休息和交谈时的BR较高。此外，76%的患者休息时的BR高于交谈时，而74%的对照者交谈时的BR高于休息时。计算了两个参数（休息时BR值以及休息时BR高于交谈时BR的模式）在区分患者和对照者方面的敏感性和特异性。当休息时BR高于每分钟27次眨眼时拟合效果最佳。当将这两个参数结合起来（休息时BR高于每分钟27次眨眼且休息时BR高于交谈时BR的模式），在区分BS患者和对照者时，我们获得了92.3%的敏感性和82.0%的特异性。这些发现表明，BR的特定特征可能与BS相关，提示对BR的分析可能有助于早期诊断BS。
