Bentivoglio A R, Bressman S B, Cassetta E, Carretta D, Tonali P, Albanese A
Istituto di Neurologia, Università Cattolica del Sacro Cuore, Roma, Italy.
Mov Disord. 1997 Nov;12(6):1028-34. doi: 10.1002/mds.870120629.
The present study measured the normal blink rate (BR) variations in relation to behavioral tasks in 150 healthy volunteers (70 males and 80 females; aged 35.9 +/- 17.9 years, range 5-87 years). The subjects were videotaped in a standard setting while performing three different tasks: resting quietly, reading a short passage, talking freely. The mean BR was computed during each task; the data were compared by means of analysis of variance and Student's t tests. Mean BR at rest was 17 blinks/min, during conversation it increased to 26, and it was as low as 4.5 while reading. As compared with rest, BR decreased by -55.08% while reading (p < 1 x 10(-15)) and increased by 99.70% during conversation (p < 1 x 10(-9)). As compared with reading, BR increased during conversation by 577.8% (p < 1 x 10(-17). The distribution curves were highly reproducible in each task. The best curve fit was represented by a log-normal distribution, with the upper tail of each curve having a normal distribution. Eye color and eyeglass wearing did not influence BR. Women had higher BR than men just while reading. No age-related differences were found. The most common BR pattern was conversation > rest > reading, which occurred in 101 subjects (67.3%); 34 subjects (22.7%) had the pattern rest > conversation > reading; 12 (8.0%) had the pattern conversation > reading > rest. This study identified three normal behavioral BR patterns and showed that BR is more influenced by cognitive processes than by age, eye color, or local factors. The present findings provide a normal reference for the analysis of BR in movement disorders such as dystonia or tics.
本研究测量了150名健康志愿者（70名男性和80名女性；年龄35.9±17.9岁，范围5 - 87岁）在进行行为任务时正常眨眼率（BR）的变化。在标准环境下对受试者进行录像，同时他们执行三项不同任务：安静休息、阅读短文、自由交谈。在每项任务期间计算平均BR；通过方差分析和学生t检验对数据进行比较。休息时的平均BR为每分钟17次眨眼，交谈时增加到26次，阅读时则低至4.5次。与休息相比，阅读时BR下降了 - 55.08%（p < 1×10⁻¹⁵），交谈时增加了99.70%（p < 1×10⁻⁹）。与阅读相比，交谈时BR增加了577.8%（p < 1×10⁻¹⁷）。在每项任务中，分布曲线具有高度可重复性。最佳曲线拟合由对数正态分布表示，每条曲线的上尾具有正态分布。眼睛颜色和是否戴眼镜不影响BR。仅在阅读时，女性的BR高于男性。未发现与年龄相关的差异。最常见的BR模式是交谈>休息>阅读，101名受试者（67.3%）呈现这种模式；34名受试者（22.7%）的模式是休息>交谈>阅读；12名（8.0%）的模式是交谈>阅读>休息。本研究确定了三种正常的行为BR模式，并表明BR受认知过程的影响大于年龄、眼睛颜色或局部因素。目前的研究结果为分析诸如肌张力障碍或抽动等运动障碍中的BR提供了正常参考。
