Lertkhachonsuk Ruangsak, Termrungruanglert Wichai, Vasuratna Apichai, Sittisomwong Tul, Worasethsin Pongkasem, Tresukosol Damrong
Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Med Assoc Thai. 2005 Sep;88 Suppl 4:S124-8.
To determine the frequency, characteristics, treatment and outcome of patients with malignant ovarian germ cell tumor (MOGCT) in King Chulalongkorn Memorial Hospital during the period January 1992 - December 2000.
Retrospective descriptive study
All patients with malignant ovarian germ cell tumor in King Chulalongkorn Memorial Hospital during the period January 1992 - December 2000 were analyzed by the characteristics of patients, treatment and outcome.
Sixty-six patients with MOGCT were demonstrated in that period with a mean age of 22.6 years old. Most of the patients were nulliparous and premenopausal status. Primary surgery was done in all patients. Forty-two patients (63.6%) received conservative surgery. Eight patients received no adjuvant treatment after surgery due to stage 1A dysgerminoma and immature teratoma stage I grade I. Fifty-six patients received chemotherapy for adjuvant treatment. VAC regimen was given in 27 cases (40.9%) and PVB regimen was given in 25 cases (37.9%). Salvage therapy in the patients with persistent and recurrent disease was treated in 9 patients, who received a platinum-base of regimen. Two-year survival was 88% with the median time to follow up 24 months. Overall five-year survival in the present study was 85%.
MOGCT in King Chulalongkorn Memorial Hospital had clinical characteristics similar to other studies in malignant ovarian germ cell tumor Treatment by VAC regimen still has benefit in selected group.
确定1992年1月至2000年12月期间朱拉隆功国王纪念医院恶性卵巢生殖细胞肿瘤（MOGCT）患者的发病率、特征、治疗方法及预后。
回顾性描述性研究
对1992年1月至2000年12月期间朱拉隆功国王纪念医院所有恶性卵巢生殖细胞肿瘤患者的患者特征、治疗方法及预后进行分析。
该时期共确诊66例MOGCT患者，平均年龄22.6岁。大多数患者未生育且处于绝经前状态。所有患者均接受了初次手术。42例患者（63.6%）接受了保守手术。8例患者因1A期无性细胞瘤和I级I期未成熟畸胎瘤术后未接受辅助治疗。56例患者接受了化疗作为辅助治疗。27例患者（40.9%）采用VAC方案，25例患者（37.9%）采用PVB方案。9例持续性和复发性疾病患者接受了挽救性治疗，采用含铂方案。两年生存率为88%，中位随访时间为24个月。本研究总体五年生存率为85%。
朱拉隆功国王纪念医院的MOGCT临床特征与其他恶性卵巢生殖细胞肿瘤研究相似。VAC方案治疗对特定组仍有益处。
