Zhao Ting, Liu Yan, Wang Xiao, Zhang Hao, Lu Yuan
1 Department of Gynaecology, Obstetrics and Gynaecology Hospital of Fudan University, Shanghai, China.
2 Department of Pathology, Obstetrics and Gynaecology Hospital of Fudan University, Shanghai, China.
J Int Med Res. 2017 Apr;45(2):771-780. doi: 10.1177/0300060517692149. Epub 2017 Jan 1.
Objective To investigate the role of ovarian cystectomy in patients with early-stage immature teratoma. Methods A retrospective review was undertaken on patients diagnosed pathologically with immature teratoma and with malignant lesions confined to the ovary. Patients were included if they had been treated between January 1997 and December 2015 at the Obstetrics and Gynaecology Hospital of Fudan University, Shanghai, China. Relevant demographic and clinical data were retrieved from the medical records. Results Forty-three patients were included in the study; 14 underwent ovarian cystectomy (group 1) and 29 underwent unilateral salpingo-oophorectomy (USO; group 2). Three of the patients who underwent USO relapsed and required a second surgical intervention. The 5-year disease-free survival rates were 100% and 88%for groups 1 and 2, respectively. There were no significant differences between the two groups in terms of survival or postoperative fertility outcomes. Univariate and multivariate analysis further revealed that ovarian cystectomy was not a poor prognostic indicator for disease-free survival. Conclusion These current data suggest that ovarian cystectomy can be considered for patients with apparent early-stage immature teratoma as it preserves fertility as much as possible without adversely impacting upon survival.
目的 探讨卵巢囊肿剔除术在早期未成熟畸胎瘤患者中的作用。方法 对经病理诊断为未成熟畸胎瘤且恶性病变局限于卵巢的患者进行回顾性研究。纳入2000年1月至2015年12月在中国上海复旦大学附属妇产科医院接受治疗的患者。从病历中检索相关人口统计学和临床资料。结果 43例患者纳入本研究；14例行卵巢囊肿剔除术（第1组），29例行单侧输卵管卵巢切除术（USO；第2组）。2例接受USO的患者复发，需要再次手术干预。第1组和第2组的5年无病生存率分别为100%和88%。两组在生存率或术后生育结局方面无显著差异。单因素和多因素分析进一步显示，卵巢囊肿剔除术不是无病生存的不良预后指标。结论 目前的数据表明，对于明显早期未成熟畸胎瘤患者可考虑行卵巢囊肿剔除术，因为该术式在不影响生存的前提下尽可能保留生育功能。
