Ksiazek Piotr, Ksiazek Andrzej
Katedra Medycyny Rodzinnej, Zakład Podstawowej Opieki Zdrowotnej Akademii Medycznej w Lublinie.
Przegl Lek. 2005;62 Suppl 2:22-5.
Recombinant human erythropoietin (rHuEPO) is a hormone essential for normal erythropoiesis. The rHuEPO receptor is distributed in the cardiovascular system predominantly in endothelial cells and cardiomyocytes. RHuEPO has potentially beneficial effects on cardiovascular system, including anti-apoptic, mitogenic and angiogenic activity. On the other hand rHuEPO improves anemia observed in some patients with heart failure. Direct cardiac activity of rHuEPO and indirect influence on anemia suggest that rHuEPO therapy is safe and useful in chronic heart failure patients and other cardiovascular settings.
重组人促红细胞生成素（rHuEPO）是正常红细胞生成所必需的一种激素。rHuEPO受体主要分布于心血管系统的内皮细胞和心肌细胞中。rHuEPO对心血管系统具有潜在的有益作用，包括抗凋亡、促有丝分裂和血管生成活性。另一方面，rHuEPO可改善一些心力衰竭患者出现的贫血症状。rHuEPO的直接心脏活性以及对贫血的间接影响表明，rHuEPO治疗对于慢性心力衰竭患者和其他心血管疾病情况是安全且有效的。
