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[糖尿病患者的自身免疫性甲状腺疾病]

[Autoimmune thyropathies in diabetics].

作者信息

Schroner Z, Lazúrová I, Petrovicová J

机构信息

NZZ interná a diabetologická ambulancia, Moldava nad Bodvou, Slovenská republika.

出版信息

Vnitr Lek. 2006 Feb;52(2):137-43.

Abstract

Autoimmune thyropathies are frequent in patients with type 1 diabetes mellitus. Some recently published papers confirm similarly high prevalence of autoimmune thyropathies also in patients with type 2 diabetes mellitus. Chronic autoimmune thyroiditis is the most frequent form of autoimmune thyropathies. Authors examined 79 accidentally selected diabetics (38 women and 41 men, x = 55.4 +/- 2.8). Diabetic patients were divided into three groups. 20 patients with type 1 diabetes mellitus - classical form were the first group, 12 patients with LADA were the second group and 47 patients with type 2 diabetes mellitus constituted the third group. Authors diagnosed chronic autoimmune thyroiditis in 8 (40 %) patients in the group of patients with type 1 diabetes mellitus, in 6 (50%) in the group of patients with LADA and in 20 (43%) of patients with type 2 diabetes mellitus. They didn't find out statistically more frequent prevalence of chronic autoimmune thyroiditis in all groups of patients with diabetes (patients with type 1 diabetes mellitus, patients with LADA, patients with type 2 diabetes mellitus) in comparison with control group of non-diabetic subjects. They found out statistically significant more frequent prevalence of chronic autoimmune thyroiditis in diabetics of woman gender and in diabetics with positive family history of thyropathies. Results of paper confirm recommendation of examining once or twice a year autoantibodies against thyroid gland and level of thyrotropin (TSH) with the aim of early finding of laboratory manifestation of thyroidal autoimmunity or developing functional disorder.

摘要

自身免疫性甲状腺疾病在1型糖尿病患者中很常见。最近发表的一些论文证实,2型糖尿病患者中自身免疫性甲状腺疾病的患病率同样很高。慢性自身免疫性甲状腺炎是自身免疫性甲状腺疾病最常见的形式。作者检查了79例随机选取的糖尿病患者(38名女性和41名男性,平均年龄 = 55.4 ± 2.8岁)。糖尿病患者被分为三组。第一组是20例1型糖尿病经典型患者,第二组是12例成人隐匿性自身免疫性糖尿病(LADA)患者,第三组是47例2型糖尿病患者。作者诊断出1型糖尿病组中有8例(40%)患者患有慢性自身免疫性甲状腺炎,LADA组中有6例(50%)患者患病,2型糖尿病组中有20例(4)患者患病。与非糖尿病对照组相比,他们未发现所有糖尿病患者组(1型糖尿病患者、LADA患者、2型糖尿病患者)中慢性自身免疫性甲状腺炎的患病率在统计学上更频繁。他们发现女性糖尿病患者和有甲状腺疾病家族史阳性的糖尿病患者中慢性自身免疫性甲状腺炎的患病率在统计学上显著更高。该论文的结果证实了建议每年检查一到两次抗甲状腺自身抗体和促甲状腺激素(TSH)水平,以便早期发现甲状腺自身免疫的实验室表现或发展为功能障碍。

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