Caumo F, Carbognin G, Casarin A, Pinali L, Vasori S, D'Onofrio M, Pozzi Mucelli R
Sezione di Radiologia, Dipartimento di Scienze Morfologico-Biomediche, Azienda Ospedaliera Policlinico G.B. Rossi, P.le L.A. Scuro 10,1-37134 Verona, Italy.
Radiol Med. 2006 Feb;111(1):61-72. doi: 10.1007/s11547-006-0007-6.
The purpose of this study was to evaluate the accuracy of angiosonography in comparison with colour Doppler ultrasound (US) in the discrimination of suspicious breast lesions with nondiagnostic fine-needle aspiration cytology (FNAC).
Pre-operative Power Doppler US and angiosonography were prospectively performed in 20 suspicious breast lesions with non-diagnostic FNAC. A second-generation US contrast agent was utilised with a high-frequency transducer and a contrast-specific algorithm (low acoustic pressure CnTI). The enhancement characteristics of all lesions were analysed using qualitative and quantitative parameters obtained from time-intensity curves with the different imaging modalities. The final diagnosis was confirmed at pathology in all cases. Microvessel density (MVD) was assessed in the surgical specimen using CD34.
The correct assessment of biological behaviour was achieved in all cases by angiosonography (sensitivity of 100%; specificity of 91%) and colour Doppler US (45% sensitivity; 78% specificity). MVD correlated with the biological behaviour.
Angiosonography is more accurate than colour Doppler US in the correct assessment of biological behaviour of suspicious breast lesions.
本研究旨在评估血管超声相对于彩色多普勒超声（US）在鉴别细针穿刺细胞学检查（FNAC）结果不明确的可疑乳腺病变方面的准确性。
对20例FNAC结果不明确的可疑乳腺病变患者进行前瞻性术前能量多普勒超声和血管超声检查。使用第二代超声造影剂、高频探头及特定的造影算法（低声压CnTI）。利用不同成像模式从时间强度曲线获得的定性和定量参数分析所有病变的增强特征。所有病例均经病理确诊。使用CD34评估手术标本中的微血管密度（MVD）。
血管超声对所有病例生物学行为的正确评估率为（敏感性100%；特异性91%），彩色多普勒超声为（敏感性45%；特异性78%）。MVD与生物学行为相关。
在正确评估可疑乳腺病变的生物学行为方面，血管超声比彩色多普勒超声更准确。
