Falappa P, Ortenzi M, Passarelli F, Micozzi M
UO Angiografia e Radiologia Interventistica, Ospedale Pediatrico Bambin Gesb, 1-00165 Roma, Italy.
Radiol Med. 2006 Feb;111(1):116-22. doi: 10.1007/s11547-006-0012-9.
We describe our experience in treating epiphora caused by chronic inflammation and obstruction of the nasolacrimal system by endonasal placement of a polyurethane stent in the nasolacrimal duct, with long-term assessment of patency (4 years).
Between July 1998 and May 2001, 57 stents were inserted using Song's technique. All procedures were carried out in the radiology suite following mild sedation and local anaesthesia of the conjunctival and nasal mucosa. The follow-up investigation concerns 23 stents assessed 24-48 months after placement.
At follow-up after 4 years, 20 stents (86.9%) were obstructed. Fifteen of the stents removed underwent histological analysis that showed occlusion of the stent with granulation tissue (eight cases), necrotic material (four cases) and fibrosis (three cases).
Although encouraging in terms of safety, simplicity and reproducibility, the results obtained with the polyurethane stent demonstrate poor long-term efficacy and stimulate the search for new strategies such as programmed stent removal or the development of a more biocompatible material.
我们描述了通过在鼻泪管内鼻置入聚氨酯支架治疗慢性炎症和鼻泪管系统阻塞引起的溢泪的经验，并对通畅情况进行了长期评估（4年）。
1998年7月至2001年5月期间，采用宋氏技术置入57个支架。所有手术均在放射科进行，术前给予轻度镇静，并对结膜和鼻粘膜进行局部麻醉。随访调查涉及23个支架，在置入后24 - 48个月进行评估。
4年随访时，20个支架（86.9%）阻塞。对取出的15个支架进行组织学分析，结果显示支架被肉芽组织阻塞（8例）、坏死物质阻塞（4例）和纤维化阻塞（3例）。
尽管聚氨酯支架在安全性、简便性和可重复性方面令人鼓舞，但长期疗效不佳，这促使人们寻找新的策略，如计划性取出支架或开发更具生物相容性的材料。
