De Boissieu D, Badoual J, Ravilly S, Lebon P
Département de pédiatrie, Hôpital Saint-Vincent-de-Paul, Paris, France.
Pediatrie. 1991;46(10):677-84.
Serum and/or cerebrospinal fluid (CSF) alpha interferon (aIFN) levels were determined in 31 neonates hospitalized for suspected sepsis. Final diagnosis was bacterial sepsis in 15, viral infection in 13 and no infection in 3. Among the 13 neonates with viral infection, enterovirus was isolated 5 times and coxsackievirus 4 times. No aIFN was found in cerebro-spinal fluid and/or serum among the neonates with bacterial sepsis or without infection. By contrast, in neonates with viral infection, CSF and/or serum aIFN levels were always elevated except in one case in which serum aIFN determination was not available. We conclude that in neonates, elevated levels of CSF and serum aIFN appear to be specific of viral infection, and that this might be helpful in the differential diagnosis of suspected sepsis.
对31名因疑似败血症住院的新生儿测定了血清和/或脑脊液（CSF）α干扰素（aIFN）水平。最终诊断为15例细菌性败血症、13例病毒感染和3例无感染。在13例病毒感染的新生儿中，5次分离出肠道病毒，4次分离出柯萨奇病毒。在细菌性败血症或无感染的新生儿的脑脊液和/或血清中未发现aIFN。相比之下，在病毒感染的新生儿中，除1例无法进行血清aIFN测定外，脑脊液和/或血清aIFN水平总是升高。我们得出结论，在新生儿中，脑脊液和血清aIFN水平升高似乎是病毒感染的特异性表现，这可能有助于疑似败血症的鉴别诊断。
