Hu Xiang-Dong, Tu Yong Qiang, Zhang En, Gao Shuanhu, Wang Shaohua, Wang Aixia, Fan Chun-An, Wang Min
State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, PRC.
Org Lett. 2006 Apr 27;8(9):1823-5. doi: 10.1021/ol060339b.
[reaction: see text] A practical and efficient total synthesis of (+/-)-galanthamine was achieved from commercially available materials through a novel approach, in which the construction of its core structure and the special allylic alcohol group were based on a successive semipinacol rearrangement/desilyation/cyclization and Saegusa-Ito oxidation, respectively.
[反应：见正文] 以市售原料通过一种新颖的方法实现了（±）-加兰他敏的实用且高效的全合成，其中其核心结构的构建和特殊的烯丙醇基团分别基于连续的半频哪醇重排/去硅基化/环化反应和Saegusa-Ito氧化反应。
