Renner Jane Dagmar Pollo, Laurino Jomar Pereira, Menna-Barreto Márcio, Schmitt Virgínia Minghelli
Instituto de Pesquisas Biomédicas, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Porto Alegre, Brazil.
AIDS Res Hum Retroviruses. 2006 Apr;22(4):301-6. doi: 10.1089/aid.2006.22.301.
Human T cell lymphotropic virus type II (HTLV-II) is a deltaretrovirus endemic in Indian populations living in Central and South America, among Pygmies tribes from Central Africa, and epidemic among injecting drug users (IDUs) in the United States, Europe, Southeast Asia, and South America. To date only the HTLV-IIa subtype has been demonstrated among Brazilians (Amazon basin Indians, blood donors, and IDUs). We analyzed HTLV-II isolates from 12 individuals living in the urban area of Porto Alegre, Southern Brazil, identified as seropositive for HTLVI/II in a blood donation. The HTLV-II long terminal repeat (LTR) region was sequenced and compared with nucleotide sequences of isolates HTLV-IIa (Mo), HTLV-IIb (NRA) prototypes. Phylogenetic analysis of the LTR region demonstrated that seven new isolates clustered together with American Indians HTLV-IIb isolates, and five new HTLV-IIa isolates clustered within the HTLV-IIa Brazilian subgroup, named the HTLV-IIc subtype. Both HTLV-IIa and IIb seem to be endemic in the urban area of Porto Alegre, South of Brazil, and could have reached this region via the Amazon basin and the Pacific Coast ancient human migratory pathways. To our knowledge this is the first study demonstrating the presence of HTLV-IIb among the urban population in Brazil.
人类嗜T细胞病毒II型（HTLV-II）是一种δ逆转录病毒，在居住于中美洲和南美洲的印第安人群体、中非俾格米部落中呈地方性流行，在美国、欧洲、东南亚和南美洲的注射吸毒者（IDU）中呈流行性传播。迄今为止，在巴西人（亚马逊流域印第安人、献血者和注射吸毒者）中仅发现了HTLV-IIa亚型。我们分析了来自巴西南部阿雷格里港市区的12名个体的HTLV-II分离株，这些个体在献血时被鉴定为HTLV-I/II血清阳性。对HTLV-II长末端重复序列（LTR）区域进行了测序，并与分离株HTLV-IIa（Mo）、HTLV-IIb（NRA）原型的核苷酸序列进行了比较。LTR区域的系统发育分析表明，7株新分离株与美洲印第安人HTLV-IIb分离株聚集在一起，5株新的HTLV-IIa分离株聚集在HTLV-IIa巴西亚组内，命名为HTLV-IIc亚型。HTLV-IIa和IIb似乎在巴西南部阿雷格里港市区呈地方性流行，可能是通过亚马逊流域和太平洋海岸古代人类迁徙途径到达该地区的。据我们所知，这是首次证明巴西城市人口中存在HTLV-IIb的研究。
