Bagnato Francesca, Ohayon Joan M, Ehrmantraut Mary, Chiu Annie W, Riva Marco, Ikonomidou Vasiliki N
Neuroimmunology Branch, NIND-NIH, 10 Center Drive, Building 10, Room 5B16, Bethesda, MD 20892-1400, USA.
Expert Rev Neurother. 2006 Apr;6(4):599-612. doi: 10.1586/14737175.6.4.599.
Multiple sclerosis (MS) is an autoimmune disease of the CNS leading to clinical disability in 250,000-350,000 young adults in the USA and Europe. The disease affects both white matter (WM) and gray matter (GM) tissues of the brain and spinal cord. While WM disease is easily quantified using currently available magnetic resonance imaging (MRI) techniques, identification and quantification of GM disease present a daily challenge. Nonconventional brain and spinal cord MRI techniques, including magnetization transfer, MRI spectroscopy and diffusion tensor imaging, have improved our understanding of MS pathology in the deep GM. The sensitivity of high-resolution MRI obtained at a high magnetic field will improve the detection of spinal cord and brain cortical GM disease. The appropriate use of the above-mentioned techniques has the potential to more accurately explain the level of disability in MS patients.
多发性硬化症（MS）是一种中枢神经系统自身免疫性疾病，在美国和欧洲，导致25万至35万年轻人出现临床残疾。该疾病会影响大脑和脊髓的白质（WM）和灰质（GM）组织。虽然使用现有的磁共振成像（MRI）技术很容易对白质疾病进行量化，但灰质疾病的识别和量化却是日常面临的挑战。包括磁化传递、磁共振波谱和扩散张量成像在内的非常规脑和脊髓MRI技术，增进了我们对深部灰质中MS病理的理解。在高磁场下获得的高分辨率MRI的敏感性将提高对脊髓和脑皮质灰质疾病的检测。合理使用上述技术有可能更准确地解释MS患者的残疾程度。
