阿片类激动剂和拮抗剂的要点。

Highlights in opioid agonists and antagonists.

作者信息

Lauretti Gabriela Rocha

机构信息

University of São Paulo, Faculty of Medicine of Ribeirão, Preto-rua Campos Sales, 330, apto 44 Ribeirâo Preto, São Paulo 15015-110, Brazil.

出版信息

Expert Rev Neurother. 2006 Apr;6(4):613-22. doi: 10.1586/14737175.6.4.613.

DOI:10.1586/14737175.6.4.613

PMID:16623659

Abstract

This review highlights new insights in to opioid agonists and antagonists, focusing on their mechanism of action with spinal and systemic administration, chronic use and main adverse effects. Short-cuts on some opioid agonists and antagonists of clinical interest are also presented, revealing potential clinical implications and future clinical directions as part of multimodal analgesia.

摘要

本综述重点介绍了阿片类激动剂和拮抗剂的新见解，着重阐述了它们经脊髓和全身给药的作用机制、长期使用情况及主要不良反应。还介绍了一些具有临床意义的阿片类激动剂和拮抗剂的捷径，揭示了作为多模式镇痛一部分的潜在临床意义和未来临床方向。