Baechler Emily C, Batliwalla Franak M, Reed Ann M, Peterson Erik J, Gaffney Patrick M, Moser Kathy L, Gregersen Peter K, Behrens Timothy W
University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Immunol Rev. 2006 Apr;210:120-37. doi: 10.1111/j.0105-2896.2006.00367.x.
Human autoimmune diseases are well suited for the application of gene expression profiling. Sampling of blood cells and target tissues has already revealed many important pathways contributing to this spectrum of disorders, and many commonalities are emerging. For instance, clinically distinct diseases such as systemic lupus erythematosus, Sjögren's syndrome, dermatomyositis, and psoriasis all show evidence for dysregulation of the type I interferon pathway. These data suggest that autoimmune diseases will eventually be categorized at the level of gene expression. This work has led to advances in our understanding of disease pathogenesis and in the future promises to facilitate assessments of disease activity and improve targeting of therapies. Here, we review the literature on gene profiling in human autoimmune diseases and provide perspective on the current state of the art.
人类自身免疫性疾病非常适合应用基因表达谱分析。对血细胞和靶组织的采样已经揭示了许多导致这类疾病的重要途径，并且许多共性正在显现出来。例如，临床上不同的疾病，如系统性红斑狼疮、干燥综合征、皮肌炎和银屑病，都显示出I型干扰素途径失调的证据。这些数据表明，自身免疫性疾病最终将在基因表达水平上进行分类。这项工作推动了我们对疾病发病机制的理解，并且有望在未来促进疾病活动的评估，改善治疗靶点的选择。在此，我们综述了关于人类自身免疫性疾病基因谱分析的文献，并对当前的技术水平提供见解。
