Tan Ya-xia, Chen Tao, Zhong Shu-qing, Li Yi-min, Chen Ying-yu, Qiu Xiao-yan, Mo Xiao-ning, Song Quan-sheng, Gan Qi-ni, Gu Ying-ying, Mo Hong-ying, Luo Wei, He Xin-ming, Liu Mu-chang, Zhong Nan-shan
Guangzhou Institute of Respiratory Disease, First Affiliated Hospital, Guangzhou Medical College, Guangzhou 510120, China.
Zhonghua Nei Ke Za Zhi. 2006 Mar;45(3):196-8.
To investigate the significance of severe acute respiratory syndrome associated coronavirus (SARS-CoV)-X4 protein expression in lungs of patients with SARS.
Pathological features of the lungs from 4 SARS patients were examined and the expression of SARS-CoV-X4 protein in the lungs was evaluated with immunohistochemical staining using specific antibodies against protein X4.
Microscopically, all lungs from 4 cases showed edema, erythrocyte and fibrin exudates in the alveoli, hyperplasia of alveolar epithelium, necrosis, hyaline membrane formation and fibroblast foci. Immunohistochemical stains showed a strong positivity of X4 protein in denudation cells, vascular endothelial cells and also erythrocytes and neutrophils in the alveoli of the lung tissues from the 4 cases.
Expression of SARS-CoV-X4 protein in the lungs may be involved in the pathogenesis and progression of SARS.
探讨严重急性呼吸综合征相关冠状病毒（SARS-CoV）-X4蛋白在严重急性呼吸综合征（SARS）患者肺组织中的表达意义。
对4例SARS患者的肺组织病理特征进行检查，并用抗X4蛋白的特异性抗体通过免疫组化染色评估肺组织中SARS-CoV-X4蛋白的表达。
显微镜下，4例患者的所有肺组织均显示肺泡水肿、红细胞和纤维蛋白渗出、肺泡上皮增生、坏死、透明膜形成和成纤维细胞灶。免疫组化染色显示，4例患者肺组织的剥脱细胞、血管内皮细胞以及肺泡内的红细胞和中性粒细胞中X4蛋白呈强阳性。
SARS-CoV-X4蛋白在肺组织中的表达可能参与了SARS的发病机制和病情进展。
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