Chen Jie, Xie Yong-qiang, Zhang Hong-tu, Wan Jian-wei, Wang De-tian, Lu Zhao-hui, Wang Qing-zhi, Xue Xin-hua, Si Wen-xue, Luo Yu-feng, Qiu Hong-mei
Department of Pathology, PUMC Hospital, CAMS, PUMC, Beijing 100730, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003 Jun;25(3):360-2.
To study the morphological features of the lungs obtained from autopsies of severe acute respiratory syndrome (SARS) patients.
Bilateral lungs from 7 patients died from SARS were carefully studied grossly and microscopically. All tissues from these cases were routinely processed and carefully studied.
All lungs from these cases were extremely expanded and became solid. Microscopically, the edema and fibrin exudates in the alveoli was the most common findings, especially in the early phase of the disease. The hyaline membrane was almost always present in the lungs of these cases. The organization of intra-alveolar fibrin exudates along with the interstitial fibrosis led to obliteration of alveoli and consolidation of lungs. The desquamation and hyperplasia of alveolar lining cells was also apparent. Foci of haemorrhage and lobular pneumonia, even diffuse fungal infection were frequently seen in these specimens. Micro-thrombus were easily found in these lungs.
The lung of SARS from autopsy is characterized by edema, intra-alveolar fibrin exudates, hyaline membrane formation, organization of intra-alveolar exudates and fibrosis, which lead to the obliteration of alveoli and consolidation of lungs.
研究严重急性呼吸综合征（SARS）患者尸检肺脏的形态学特征。
对7例死于SARS的患者的双侧肺脏进行仔细的大体和显微镜检查。对这些病例的所有组织进行常规处理并仔细研究。
这些病例的所有肺脏均极度膨胀并实变。显微镜下，肺泡内水肿和纤维蛋白渗出是最常见的表现，尤其是在疾病早期。这些病例的肺脏几乎均可见透明膜。肺泡内纤维蛋白渗出物机化及间质纤维化导致肺泡闭塞和肺实变。肺泡衬里细胞的脱落和增生也很明显。这些标本中经常可见出血灶和小叶性肺炎，甚至弥漫性真菌感染。这些肺脏中很容易发现微血栓。
SARS尸检肺脏的特征为水肿、肺泡内纤维蛋白渗出、透明膜形成、肺泡内渗出物机化和纤维化，导致肺泡闭塞和肺实变。
