白血病抑制因子受体基因与德国牧羊犬垂体性侏儒症的病因无关。

The leukemia inhibitory factor receptor gene is not involved in the etiology of pituitary dwarfism in German shepherd dogs.

作者信息

Hanson J M, Mol J A, Leegwater P A J, Kooistra H S, Meij B P

机构信息

Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, P.O. Box 80.154, NL-3508 TD Utrecht, The Netherlands.

出版信息

Res Vet Sci. 2006 Dec;81(3):316-20. doi: 10.1016/j.rvsc.2006.03.001. Epub 2006 Apr 19.

DOI:10.1016/j.rvsc.2006.03.001

PMID:16624355

Abstract

Pituitary dwarfism in German shepherd dogs is characterized by combined pituitary hormone deficiency (CPHD) and intrapituitary cyst formation. Activation of the leukemia inhibitory factor (LIF)-LIF receptor (LIFR) signal transduction pathway results in a similar phenotype in (transgenic) mice. We therefore assessed the role of the LIFR in the etiology of pituitary dwarfism in German shepherd dogs. A polymorphic microsatellite marker (UULIFR) was used to analyze the segregation of the LIFR gene in 22 German shepherd dogs from 4 pedigrees, each including one dwarf. There was no allelic association between UULIFR and the dwarfism phenotype. Based on our findings LIFR was excluded as a candidate gene for CPHD.

摘要

德国牧羊犬的垂体性侏儒症的特征是垂体激素联合缺乏（CPHD）和垂体囊肿形成。白血病抑制因子（LIF）-LIF受体（LIFR）信号转导途径的激活在（转基因）小鼠中导致类似的表型。因此，我们评估了LIFR在德国牧羊犬垂体性侏儒症病因中的作用。使用一个多态微卫星标记（UULIFR）分析了来自4个家系的22只德国牧羊犬中LIFR基因的分离情况，每个家系包括一只侏儒犬。UULIFR与侏儒症表型之间没有等位基因关联。基于我们的研究结果，LIFR被排除为CPHD的候选基因。