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德国牧羊犬的垂体性侏儒症:简单常染色体隐性遗传的更多证据。

Pituitary dwarfism in German shepherd dogs: additional evidence of simple, autosomal recessive inheritance.

作者信息

Andresen E, Willeberg P

出版信息

Nord Vet Med. 1976 Oct;28(10):481-6.

PMID:980693
Abstract

Previous observations suggested that pituitary dwarfism of German Shepherd dogs is due to simple, autosomal recessive inheritance, but own data were insufficient to test the hypothesis. The total material now includes six dwarfs from five litters. Omitting the proband litter, a total of 21 dogs from four litters, each with one dwarf, were relevant for testing goodness of fit. The observed segregation ratio was in agreement with that expected and thus supported the genetic hypothesis. According to this hypothesis it was possible to point at various heterozygous carriers among ancestors of the dwarfs within a pedigree comprising 13 generations.

摘要

先前的观察结果表明,德国牧羊犬的垂体性侏儒症是由简单的常染色体隐性遗传所致,但我们自己的数据不足以验证这一假设。目前的全部资料包括来自五窝的6只侏儒犬。除去先证者那一窝,来自四窝的总共21只犬(每窝有1只侏儒犬)与适合度检验相关。观察到的分离比与预期相符,因此支持了该遗传学假设。根据这一假设,在一个包含13代的家系中,可以指出侏儒犬祖先中的各种杂合子携带者。

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Pituitary dwarfism in German shepherd dogs: additional evidence of simple, autosomal recessive inheritance.德国牧羊犬的垂体性侏儒症:简单常染色体隐性遗传的更多证据。
Nord Vet Med. 1976 Oct;28(10):481-6.
2
Pituitary dwarfism in German shepherd dogs: genetic investigations.德国牧羊犬的垂体性侏儒症:遗传学研究
Nord Vet Med. 1974 Dec;26(12):692-701.
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The leukemia inhibitory factor receptor gene is not involved in the etiology of pituitary dwarfism in German shepherd dogs.白血病抑制因子受体基因与德国牧羊犬垂体性侏儒症的病因无关。
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Pituitary dwarfism in german shepherd dogs: studies on somatomedin activity.德国牧羊犬的垂体性侏儒症:生长调节素活性研究
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Exclusion of the lim homeodomain gene LHX4 as a candidate gene for pituitary dwarfism in German shepherd dogs.德国牧羊犬垂体性侏儒症候选基因中lim同源结构域基因LHX4的排除。
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Pituitary dwarfism in Carelian bear-dogs: evidence of simple, autosomal recessive inheritance.卡累利阿熊犬的垂体性侏儒症:简单常染色体隐性遗传的证据。
Hereditas. 1977 Feb 3;84(2):232-4. doi: 10.1111/j.1601-5223.1977.tb01400.x.
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[Hypopituitarism associated dwarfism in German Shepherds, saarloos wolf dogs and Czechoslovakian wolf dogs. Access to genetic testing].[德国牧羊犬、萨尔路斯狼犬和捷克斯洛伐克狼犬中的垂体功能减退相关侏儒症。基因检测途径]
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Cloning of the canine gene encoding transcription factor Pit-1 and its exclusion as candidate gene in a canine model of pituitary dwarfism.犬类编码转录因子Pit-1基因的克隆及其在垂体性侏儒症犬模型中作为候选基因的排除。
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引用本文的文献

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Wellbeing, quality of life, presence of concurrent diseases, and survival times in untreated and treated German Shepherd dogs with dwarfism.未治疗和治疗的德国牧羊犬矮小型犬的生存时间、福利、生活质量、共存疾病情况。
PLoS One. 2021 Aug 9;16(8):e0255678. doi: 10.1371/journal.pone.0255678. eCollection 2021.
2
Dwarfism in Tibetan Terrier dogs with an mutation.藏獒犬突变引起的矮小症。
J Vet Diagn Invest. 2021 Jul;33(4):740-743. doi: 10.1177/10406387211007526. Epub 2021 Apr 23.
3
Atlanto-axial malformation and instability in dogs with pituitary dwarfism due to an LHX3 mutation.
因LHX3突变导致垂体性侏儒症的犬类寰枢椎畸形与不稳定
J Vet Intern Med. 2015 Jan;29(1):207-13. doi: 10.1111/jvim.12523. Epub 2015 Jan 14.
4
Pituitary dwarfism in Saarloos and Czechoslovakian wolfdogs is associated with a mutation in LHX3.萨阿路斯狼犬和捷克斯洛伐克狼犬的垂体性侏儒症与LHX3基因的突变有关。
J Vet Intern Med. 2014 Nov-Dec;28(6):1770-4. doi: 10.1111/jvim.12448. Epub 2014 Oct 1.
5
A contracted DNA repeat in LHX3 intron 5 is associated with aberrant splicing and pituitary dwarfism in German shepherd dogs.LHX3 内含子 5 中的一个 DNA 重复序列与德国牧羊犬的异常剪接和垂体性矮小相关。
PLoS One. 2011;6(11):e27940. doi: 10.1371/journal.pone.0027940. Epub 2011 Nov 23.
6
Genome-wide association studies for multiple diseases of the German Shepherd Dog.用于德国牧羊犬多种疾病的全基因组关联研究。
Mamm Genome. 2012 Feb;23(1-2):203-11. doi: 10.1007/s00335-011-9376-9. Epub 2011 Nov 22.