三代α,γ-二氨基丁酸修饰的聚（丙烯亚胺）树枝状大分子及其顺铂型铂配合物。

Three generations of alpha,gamma-diaminobutyric acid modified poly(propyleneimine) dendrimers and their cisplatin-type platinum complexes.

作者信息

Bellis E, Hajba L, Kovács B, Sándor K, Kollár L, Kokotos G

机构信息

University of Athens, Laboratory of Organic Chemistry, 15771 Athens, Greece.

出版信息

J Biochem Biophys Methods. 2006 Nov 30;69(1-2):151-61. doi: 10.1016/j.jbbm.2006.02.006. Epub 2006 Mar 9.

DOI:10.1016/j.jbbm.2006.02.006

PMID:16624417

Abstract

Three generations of alpha,gamma-diaminobutyric acid modified poly(propyleneimine) dendrimers [DAB(AM)n, n = 4, 8, 16] containing 4, 8, 16 free amino groups were coupled with Boc-protected alpha,gamma-diaminobutyric acid (DABA) moieties in high yields. These modified dendrimers were deprotected and the chiral dendritic amines with 8, 16 and 32 amino groups on the surface were isolated in excellent yields. Dendrimers with cisplatin moieties at the periphery were obtained in the reaction of the free amine dendrimers and potassium tetrachloroplatinate(II). The highly insoluble complexes were isolated as hydrates and characterized by means of IR, TGA and elemental analysis.

摘要

三代含有4、8、16个游离氨基的α,γ-二氨基丁酸修饰的聚（丙烯亚胺）树枝状大分子[DAB(AM)n，n = 4、8、16]与Boc保护的α,γ-二氨基丁酸（DABA）部分以高产率偶联。这些修饰的树枝状大分子被脱保护，表面带有8、16和32个氨基的手性树枝状胺以优异的产率分离出来。游离胺树枝状大分子与四氯铂酸钾（II）反应得到外围带有顺铂部分的树枝状大分子。高度不溶的配合物以水合物形式分离出来，并通过红外光谱、热重分析和元素分析进行表征。