Sano Hideki, Bonadio Jeffrey, Gerbing Robert B, London Wendy B, Matthay Katherine K, Lukens John N, Shimada Hiroyuki
Department of Pathology and Laboratory Medicine, Childrens Hospital Los Angeles, and Keck School of Medicine, University of Southern California, 4650 Sunset Blvd. M.S. #43, Los Angeles, CA 90027, United States.
Eur J Cancer. 2006 May;42(8):1113-9. doi: 10.1016/j.ejca.2005.11.031. Epub 2006 Apr 18.
Age has been used as a prognostic factor for patients with peripheral neuroblastic tumours (pNTs). The latest analysis disclosed a cut-off around 18 months for the optimal prognostic distinction. The International Neuroblastoma Pathology Classification (INPC) distinguishes favourable and unfavourable histology based on the age-appropriate evaluation of histologic indicators (grade of neuroblastic differentiation, mitosis-karyorrhexis index) in the categories of neuroblastoma and ganglioneuroblastoma, nodular. This study showed that age tested by using 3 different cut-offs (12, 18, 24 months) was prognostically significant. INPC remained prognostically significant regardless of the age group to which it was applied. Prognostic effects of age and histologic indicators were independently significant, i.e., age had prognostic ability beyond that of histologic indicators, and histologic indicators had prognostic ability beyond that of age. Due to the fact that INPC incorporated age factor (18, 60 months) in the system, it served better than age by itself for prognostic distinction of pNT patients.
年龄已被用作外周神经母细胞瘤（pNTs）患者的预后因素。最新分析显示，约18个月是进行最佳预后区分的临界值。国际神经母细胞瘤病理分类（INPC）根据神经母细胞瘤和节细胞神经母细胞瘤（结节型）类别中组织学指标（神经母细胞分化程度、有丝分裂-核溶解指数）的适年龄评估来区分预后良好和预后不良的组织学类型。本研究表明，采用3个不同临界值（12、18、24个月）检测的年龄具有预后意义。无论应用于哪个年龄组，INPC均具有预后意义。年龄和组织学指标的预后作用均具有独立意义，即年龄具有超出组织学指标的预后能力，组织学指标具有超出年龄的预后能力。由于INPC在系统中纳入了年龄因素（18、60个月），因此它在pNT患者的预后区分方面比单独使用年龄表现更好。
