游离脂肪移植或纤维素膜植入物对犬椎板切除术后瘢痕形成的影响。

The effects of free fat graft or cellulose membrane implants on laminectomy membrane formation in dogs.

作者信息

da Costa Ronaldo C, Pippi Ney L, Graça Dominguita L, Fialho Sérgio A, Alves Aline, Groff Ana C, Rezler Ubiratã

机构信息

Department of Veterinary Medicine, Federal University of Paraná, Campus Palotina, Palotina, PR 85950-000, Brazil.

出版信息

Vet J. 2006 May;171(3):491-9. doi: 10.1016/j.tvjl.2004.12.011.

DOI:10.1016/j.tvjl.2004.12.011

PMID:16624715

Abstract

The purpose of this study was to determine the effect of cellulose membrane or free fat grafts (FFG) on laminectomy membrane (LM) formation. Eighteen dogs were randomly divided into three groups of six dogs. All dogs underwent a modified dorsal laminectomy on T(13)-L(1). The laminectomy defect was left uncovered in the control group but either a FFG or a cellulose membrane implant was provided in the other two groups. The dogs were evaluated through neurological examination, myelography, macroscopic roundness index of spinal cord and histological evaluations of epidural fibrosis and spinal cord. The results showed a significant difference between the control and the FFG group, with the FFG causing neurological deficits and spinal cord compression as assessed by the roundness index of the spinal cord. Both FFG and cellulose membrane were partially effective in preventing LM formation. The use of FFG was associated with a high rate of significant neurological complications and spinal cord lesions.

摘要

本研究的目的是确定纤维素膜或游离脂肪移植（FFG）对椎板切除膜（LM）形成的影响。18只狗被随机分为三组，每组6只。所有狗均接受了T13 - L1节段的改良后路椎板切除术。对照组的椎板切除缺损未覆盖，但其他两组分别植入了FFG或纤维素膜。通过神经学检查、脊髓造影、脊髓宏观圆度指数以及硬膜外纤维化和脊髓的组织学评估对狗进行评价。结果显示，对照组和FFG组之间存在显著差异，根据脊髓圆度指数评估，FFG导致神经功能缺损和脊髓受压。FFG和纤维素膜在预防LM形成方面均有部分效果。使用FFG与较高的严重神经并发症和脊髓损伤发生率相关。