Chevin Luis-Miguel, Hospital Frédéric
UMR de Génétique Végétale du Moulon, INRA/Université Paris XI/CNRS/INA P-G, 91190 Gif-sur-Yvette, France.
Genetics. 2006 Jul;173(3):1829-32. doi: 10.1534/genetics.105.052977. Epub 2006 Apr 19.
Transmission-ratio distortion is a departure from a 1:1 segregation of alleles in the gametes of a heterozygous individual. The so-called driving allele is strongly selected regardless of its effect on the fitness of the carrying individual. It may then have an important impact on neutral polymorphism due to the genetic hitchhiking effect. We study this hitchhiking effect in the case of true meiotic drive in autosomes and show that it is more dependent on the recombination rate than in the classical case of a gene positively selected at the organism level.
传递比率失真指杂合个体配子中等位基因的分离偏离1:1的比例。所谓的驱动等位基因会被强烈选择,而不论其对携带该等位基因个体适合度的影响。由于遗传搭便车效应,它可能会对中性多态性产生重要影响。我们研究了常染色体上真正减数分裂驱动情况下的这种搭便车效应,结果表明,与在生物体水平上受到正向选择的基因的经典情况相比,它对重组率的依赖性更强。